220851-34-3

Upstream product

• 1776-53-0 4-aminocyclohexanecarboxylic acid 
• 31139-36-3 dibenzyl dicarbonate 
• 854446-76-7 (1R,4R)-4-aminocyclohexanecarboxylic acid hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1187564-08-4 C₂₇H₃₈N₂O₈ 
• 1187564-03-9 4-[2-(2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-cyclohexanecarboxylic acid (2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amide 
• 1187564-10-8 C₁₉H₃₂N₂O₆ 
• 412357-47-2 trans-4-benzyloxycarbonyl-amino-N-(2-hydroxyphenyl)cyclohexanecarboxamide 
• 138848-78-9 {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester 
• 103892-60-0 4-Amino-cyclohexanecarboxylic acid [(S)-5-amino-1-(4-benzoyl-phenylcarbamoyl)-pentyl]-amide 

Relevant academic research and scientific papers

MACROCYCLES AND THEIR USES

The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases

Tri-substituted heteroaryls and methods of making and using the same

Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of the general formula (I).

GLUTARAMIDE DIURETIC AGENTS

A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent completes a 5-or 6-membered carbocycyclic ring and is located at the carbon atom adjacent to the carbamoyl group. These particular compounds are inhibitors of the neutral endopeptidase E.C.3.4.24.11 enzyme and are therefore useful in therapy as diuretic agents for the treatment of hypertension, heart failure, renal insufficiency and other disorders. Methods for preparing these compounds from known starting materials are provided.