22086-03-9

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 2362-79-0 N-(4-chlorobenzylidene)aniline 
• 40339-48-8 N-((Z)-4-chloro-benzylidene)-aniline 
• 598-99-2 Methyl trichloroacetate 
• 25436-07-1 trimethylsilyl trichloroacetate 
• 4124-31-6 trichloroacetic acid anhydride 
• 1613-95-2 (E)-1-(4-chlorophenyl)-N-phenylmethanimine 
• 62-53-3 aniline 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

3,3-Dichloro-4-(4-chlorophenyl)-1-phenylazetidin-2-one

In molecules of C15H10Cl3NO, the four-membered lactam ring is nearly planar, with a C - N bond length of 1.367 (4) A in the amide group and C - C distances of 1.535 (5) and 1.566 (5) A. The displacement of the amide N atom from the plane through the atoms attached to it is 0.056 (3) A, indicating some pyramidal character which is correlated to the biological activity in related compounds. The phenyl rings are nearly perpendicular to one another [dihedral angle 79.4 (1)°]. There are intramolecular and intermolecular hydrogen bonds in the structure.

Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones

Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and 1H NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested. Copyright (C) 2000 Elsevier Science S.A.

Reaction of Imines with Trichloroacetic Esters or Anhydride Promoted by Iron Carbonyl or Microwave Irradiation. Preparation of 3,3-Dichloro-β-Lactams

The synthesis of 3,3-dichloroazetidin-2-ones by the reaction of imines and methyl or trimethylsilyl trichloroacetate promoted by diiron nonacarbonyl or by microwave irradiation of imines and trichloroacetic anhydride is described.