220861-36-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 220861-41-6 (Z/E)-(R)-3-(tert-Butyldimethylsilyloxy)-pent-4-enal oxime 
• 220861-59-6 (R)-tert-butyl 3-((tert-butyldimethylsilyl)oxy)pent-4-enoate 
• 220861-39-2 (R)-3-((tert-butyldimethylsilyl)oxy)pent-4-enal 
• 220861-37-0 (R)-tert-butyl 3-hydroxypent-4-enoate 
• 22927-31-7 4-oxobutyl benzoate 

Downstream Products

• 350246-27-4 (2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester 
• 350246-31-0 (2S,3R,4R)-N-Benzyloxycarbonyl-2-(3-tosyloxypropyl)-4-(tert-butyldimethylsilyloxy)-3-hydroxy-3-methylpiperidine 
• 350246-26-3 (2S,3S,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester 
• 350246-28-5 (2S,4R)-N-Benzyloxycarbonyl-2-(3-benzoyloxypropyl)-4-(tert-butyldimethylsilyloxy)-3-methylene-piperidine 
• 350246-29-6 (2S,4R)-N-Benzyloxycarbonyl-2-(3-benzoyloxypropyl)-4-(tert-butyldimethylsilyloxy)piperidin-3-one 
• 350246-30-9 (2S,3R,4R)-N-Benzyloxycarbonyl-2-(3-hydroxypropyl)-4-(tert-butyldimethylsilyloxy)-3-hydroxy-3-methylpiperidine 

Relevant academic research and scientific papers

Stereoselective synthesis of the indolizidine core of the allopumiliotoxins

The common indolizidine core leading to the allopumiliotoxins was synthesized using an intramolecular (Z)-N-4-alkenylnitrone cycloaddition reaction as the key step. The synthesis began with (R)-tert-butyl-3- hydroxypent-4-enoate which was obtained via enzymatic resolution using Amano PS lipase.