Stereoselective synthesis of the indolizidine core of the allopumiliotoxins

Article abstract of DOI:10.1016/S0040-4039(98)02618-5

The common indolizidine core leading to the allopumiliotoxins was synthesized using an intramolecular (Z)-N-4-alkenylnitrone cycloaddition reaction as the key step. The synthesis began with (R)-tert-butyl-3- hydroxypent-4-enoate which was obtained via enzymatic resolution using Amano PS lipase.