220862-05-5

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 1539304-68-1 3-(allyloxy)-5-methoxybenzyl alcohol 
• 57179-35-8 3-hydroxy-5-methoxybenzaldehyde 
• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 681443-55-0 3-(allyloxy)-5-methoxybenzaldehyde 
• 40359-32-8 3-allyloxy-benzaldehyde 

Relevant academic research and scientific papers

Synthetic methods for phoyunbenes A-D and thunalbene

Invented is a method for synthesizing thunalbene and phoyunbenes A-D via a Horner-Wadsworth-Emmons (HWE) reaction in a simple and effective way. The compounds of the present invention have shown anti-inflammatory effects in RAW-264.7 macrophage which is induced by lipopolysaccharide.

Syntheses of phoyunbenes A-D and thunalbene for their anti-inflammatory evaluation

Simple and efficient first syntheses of phoyunbenes A-D and thunalbene have been developed using Horner- Wadsworth-Emmons reaction as a key step. Later, their anti-inflammatory effects were investigated in lipopolysaccharide-induced RAW-264.7 macrophages. The results revealed that phoyunbenes A-D and thunalbene showed weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator.