220867-48-1

Basic information

• Product Name: 5'-azido-N⁶-benzoyl-3',5'-dideoxyadenosine
• Synonyms: 5'-azido-N⁶-benzoyl-3',5'-dideoxyadenosine
• CAS NO: 220867-48-1
• Molecular Weight: 380.366
• Mol File: 220867-48-1.mol

Chemical Properties

• CAS DataBase Reference: 5'-azido-N⁶-benzoyl-3',5'-dideoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-azido-N⁶-benzoyl-3',5'-dideoxyadenosine(220867-48-1)
• EPA Substance Registry System: 5'-azido-N⁶-benzoyl-3',5'-dideoxyadenosine(220867-48-1)

Safety Data

• Hazardous Substances Data: 220867-48-1(Hazardous Substances Data)

Upstream product

• 76902-49-3 N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 220867-47-0 N⁶-benzoyl-3'-deoxy-5'-O-<(p-toluyl)sulfonyl>adenosine 

Downstream Products

• 220867-54-9 3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 2'-O-<2-cyanoethyl diisopropylphosphoramidite> 
• 220867-49-2 3',5'-dideoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>-5'-<<2-(4-nitrophenyl)ethoxycarbonyl>amino>adenosine 

Relevant articles and documents

Synthesis and biological activity of (2'-5')oligoadenylate trimers containing a 5'-terminal 5'-amino-5'-deoxy- or 5'-amino-3',5'- dideoxyadenosine derivative

The new (2'-5')oligoadenylate trimers 26-34 containing 5'-amino-5'- deoxyadenosine or 5'-amino-3',5'-dideoxyadenosine or their lipophilic 5'- deoxy-5'-(hexadecanoylamino) derivatives at the 5'-terminus, and adenosine or 3'-deoxyadenosine (=cordycepin) at the penultimate and T-end position of the trimers were synthesized by the phosphoramidite method. The newly synthesized trimers 26-34 inhibited, at 100 μM concentration, HIV-1-induced syncytia formation (SYN) by 19-96% and reverse-transcriptase activity (RT) by 27-100% (see Table). The two hexadecanoylamino derivatives 27 and 30 which were found to be potent inhibitors of SYN and RT showed also a 73 and 49% inhibition, respectively, of expression of HIV-1 p24 antigen (p24-EX). The same compounds 27 and 30 inhibited also, with a 100% efficacy, an amplification of HIV-1 partial reverse transcripts (PCR) and HIV-1 integrase activity (INT), respectively.