220873-29-0Relevant articles and documents
Indolocarbazole poisons of human topoisomerase I: Regioisomeric analogues of ED-110
Zembower, David E.,Zhang, Heping,Lineswala, Jayana P.,Kuffel, Mary J.,Aytes, Shelley A.,Ames, Matthew M.
, p. 145 - 150 (2007/10/03)
All four 'symmetrical' regioisomers of ED-110, an indolocarbazole derivative having potent activity against human topoisomerase I (Topo I) were synthesized. The isomer containing hydroxyl groups in the 3- and 9-positions was approximately ten-fold more active against Topo I, and 5- to 35-fold more active against human solid tumor cell lines in vitro, relative to ED-110.