220875-85-4

Usage

Uses

Used in Pharmaceutical Industry:
1-Benzylcyclopentanecarboxylic acid is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with unique mechanisms of action.
Used in Agrochemical Industry:
In the agrochemical sector, 1-benzylcyclopentanecarboxylic acid is utilized as a building block in the creation of agrochemicals, potentially enhancing crop protection and yield through novel chemical entities.
Used in Functional Materials:
1-BENZYLCYCLOPENTANECARBOXYLIC ACID serves as a precursor in the development of functional materials, where its structural attributes can be leveraged to impart specific properties to these materials, such as improved stability or reactivity.
Used in Drug Design and Development:
1-Benzylcyclopentanecarboxylic acid is employed as a structural component in drug design, capitalizing on its unique features to engineer new therapeutic agents with potential applications in various medical fields.
Used in Anti-inflammatory and Analgesic Applications:
Due to its inherent anti-inflammatory and analgesic properties, 1-benzylcyclopentanecarboxylic acid is considered for the development of new therapeutics aimed at treating conditions associated with pain and inflammation.

Upstream product

• 100-39-0 benzyl bromide 
• 4630-80-2 methyl cyclopentane carboxylate 
• 620-05-3 iodomethylbenzene 
• 784182-12-3 1-benzyl-cyclopentanecarboxylic acid methyl ester 

Downstream Products

• 1613145-80-4 1-benzyl-N-(8-quinolinyl)cyclopentanecarboxamide 
• 1613146-08-9 3-phenyl-2-(8-quinolinyl)-2-azaspiro[3.4]-1-octanone 
• 220876-48-2 4-nitro-N-[[1-(phenylmethyl)cyclopentyl]carbonyl]-L-phenylalanine methyl ester 

Relevant academic research and scientific papers

Nickel-catalyzed site-selective amidation of unactivated C(sp 3)-H bonds

Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp3 carbon atoms by a nickel-catalyzed C-H bond functionalization process with the assistance of a bidentate directing group. The reaction favors the C-H bonds of β-methyl groups over the γ-methyl or β-methylene groups. Additionally, a predominant preference for the β-methyl C-H bonds over the aromatic sp2 C-H bonds was observed. Moreover, this process also allows for the effective functionalization of benzylic secondary sp3 C-H bonds. β-Lactams from nickel catalysis: Intramolecular dehydrogenative cyclization of aliphatic amides was achieved on unactivated sp3 carbon atoms by a nickel-catalyzed C-H bond functionalization process with the assistance of a bidentate directing group (see scheme).

N-alkanoylphenylalanine derivatives

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

N-Cycloalkanoyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.

A systematic structure-activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl)cycloalkanoyl]-4-[((2,6-dichlorophenyl)carbonyl)amino]-L-phenylalanine derivatives as potent VCAM/VLA-4 antagonists. The data are consistent with a model of these compounds in which these alkanoylphenylalanines reside in a compact gauche (-) bioactive conformation.