220876-23-3

Upstream product

• 861359-74-2 diisopropylethyl amine 
• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 17193-40-7 (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride 
• 220880-33-1 N-[(1-phenylcyclopentyl)carbonyl]-4-nitro-L-phenylalanine methyl ester 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 949-99-5 4-nitro-3-phenyl-L-alanine 

Downstream Products

• 220876-24-4 N-[(1-phenylcyclopentyl)carbonyl]-4-[(4-quinolinylcarbonyl)amino]-L-phenylalanine sodium salt 
• 252327-79-0 N-(1-phenyl-1-cyclopentanecarbonyl)-N'-(2,6-dichlorobenzoyl)-L-4-aminophenylalanine methyl ester 

Relevant academic research and scientific papers

N-alkanoylphenylalanine derivatives

Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists.

A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists char