252327-79-0

Upstream product

• 220876-23-3 N-[(1-Phenylcyclopentyl)carbonyl]-4-amino-L-phenylalanine Methyl Ester 
• 50-30-6 2,6-dichlorobenzoic acid 
• 220880-33-1 N-[(1-phenylcyclopentyl)carbonyl]-4-nitro-L-phenylalanine methyl ester 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 949-99-5 4-nitro-3-phenyl-L-alanine 

Relevant academic research and scientific papers

Phenylalanine derivatives

Phenylalanine derivatives of formula (1) are described: wherein L1 is a linker atom or group;X1 is a group selected from —N(R3)CO—, —N(R3)SO2—, —N(R3)C(O)O— or—N(R3)CON(R3a

Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists.

A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists char