220886-33-9Relevant academic research and scientific papers
Reactivity and selectivity in the oxidation of styrene derivatives. V. studies on the oxidation of α-substituted styrenes
Suprun
, p. 52 - 58 (1999)
The liquid phase oxidation of α-phenyl-1a, α-trimethylsilyloxy 1b, α-cyclopropyl-1c, α-trifluoromethyl-1d styrene, and styrene 1e with oxygen in chlorobenzene and cumene solution in the temperature range 55-125°C was investigated. The product yields were determined gaschromatographically. The epoxide selectivity increases up to 90°C with increasing temperature. The epoxides of 1a and 1c rearrange at higher temperatures, therefore their yield decreases. The relative chain propagation constants (kpC=C) were determined by competitive oxidations of cumene. WILEY-VCH Verlag GmbH, 1999.
Highly chemoselective rhodium-catalyzed methylenation of fluorine-containing ketones.
Lebel, Helene,Paquet, Valerie
, p. 1671 - 1674 (2007/10/03)
[reaction: see text] The rhodium(I)-catalyzed methylenation of functionalized fluorinated ketones using trimethylsilyldiazomethane proceeds to give the corresponding fluoromethylalkenes in good yields (61-90%). Remarkable chemoselectivity was observed for
Enantioselective synthesis of α-hydroxyacids through oxidation of terminal alkenes with AD-mix/TEMPO
Javier Aladro,Guerra, Francisco M.,Javier Moreno-Dorado,Bustamante, Jesús M.,Jorge, Zacarías D.,Massanet, Guillermo M.
, p. 3209 - 3213 (2007/10/03)
α-Hydroxyacids can be enantioselectively prepared by means of a two- step oxidation process, involving first the asymmetric dihydroxylation of a terminal alkene and subsequent oxidation with TEMPO/NaOCl/NaClO2 in good to excellent yields. No fragmentation of the glycol intermediate was detected. (C) 2000 Elsevier Science Ltd.
