22090-24-0

Usage

Uses

Used in Pharmaceutical Industry:
4-PIPERIDIN-1-YL-BENZOIC ACID is used as a building block for the synthesis of various drugs, particularly as a precursor in the production of psychiatric medications and antihistamines. Its structural features and chemical reactivity make it a valuable component in the development of new pharmaceutical compounds.
Used in Research and Development:
4-PIPERIDIN-1-YL-BENZOIC ACID is used in the research and development of organic compounds and materials due to its versatile chemical reactivity and structural features. This allows scientists to explore its potential in creating new compounds with specific therapeutic properties or applications in material science.
Used in Anti-Inflammatory and Analgesic Applications:
4-PIPERIDIN-1-YL-BENZOIC ACID is used as a potential anti-inflammatory and analgesic agent, given its inherent properties that may contribute to the development of new therapeutic agents for the treatment of pain and inflammation. Its potential in this area is currently being explored for future applications in medicine.

InChI:InChI=1/C12H15NO2/c14-12(15)10-4-6-11(7-5-10)13-8-2-1-3-9-13/h4-7H,1-3,8-9H2,(H,14,15)/p-1

Upstream product

• 1204-85-9 4-(piperidin-1-yl)benzonitrile 
• 111-24-0 1,5-dibromo-pentane 
• 150-13-0 4-amino-benzoic acid 
• 110-89-4 piperidine 
• 456-22-4 4-Fluorobenzoic acid 
• 1194-02-1 4-fluorobenzonitrile 
• 623-00-7 4-bromobenzenecarbonitrile 
• 101038-65-7 ethyl 4-(piperidine-1-yl)benzoate 
• 10338-58-6 N-(4-[methyl 4-benzoxycarbonyl])piperidine 
• 10342-85-5 4-piperidinoacetophenone 
• 1171309-72-0 2-oxo-2-[4-(1-piperidinyl)phenyl]acetaldehyde monohydrate 
• 10338-57-5 4-(piperidin-1-yl)benzaldehyde 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 106947-67-5 4-(1-Oxy-piperidin-1-yl)-benzoic acid 
• 221360-47-0 (S)-N-[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-4-piperidinobenzamide 
• 151296-46-7 4-Piperidinobenzoylguanidine hydrochloride 
• 1140460-77-0 1-(4-{3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}phenyl)piperidine 
• 1616961-20-6 N-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-(piperidin-1-yl)benzamide 
• 1616960-78-1 N-(2-(2-methyl-1H-indol-1-yl)ethyl)-4-(piperidin-1-yl)benzamide 
• 10338-58-6 N-(4-[methyl 4-benzoxycarbonyl])piperidine 

Relevant academic research and scientific papers

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, trifluoperazine and thioridazine. Combined HTS (11000 compounds) and in-house screening of a limited number of quinolones (50 compounds) identified ～100 hits and four distinct chemotypes, the most promising of which contained the quinolone core. Subsequent Mtb screening of the complete in-house quinolone library (350 compounds) identified a further ～90 hits across three quinolone subtemplates. Quinolones containing the amine-based side chain were selected as the pharmacophore for further modification, resulting in metabolically stable quinolones effective against multi drug resistant (MDR) Mtb. The lead compound, 42a (MTC420), displays acceptable antituberculosis activity (Mtb IC50 = 525 nM, Mtb Wayne IC50 = 76 nM, and MDR Mtb patient isolates IC50 = 140 nM) and favorable pharmacokinetic and toxicological profiles.

COMPOUNDS FOR TREATING VIRAL INFECTIONS

The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).

Preparation of pyrido [2,3-b] pyrazine ring system via regioselective condensation reaction

The pyrido[2,3-b]pyrazine core structure can be found in several molecules that express biological activity. We have previously published a series of these compounds that showed erlotinib-resistant tumor inhibitor potential. The common way of their synthe

OXADIAZOLE DIARYL COMPOUNDS

The invention relates to compounds of formula (I): wherein R1, R2, Ra , Rb,Rc and W, have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.

Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists

This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).

New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture

The present invention relates to carboxamide compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1, R2, R3 and k have the meanings given in claim 1. Moreover the invention relates to process for preparing the above mentioned carboxamides as well as pharmaceutical compositions containing at least one carboxamide according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.

Studies of Tetriary Amine Oxides. 9. Thermal Rearrangement of 1-(4-Substituted-phenyl)piperidine N-Oxides to the Corresponding N-Hydroxylamines

(4-Substituted - phenyl)piperidine N-oxides undergo a thermal rearrangement to O-arylhydroxylamines.Electron withdrawing substituents are essential for the rearrangement and must be ortho or para relative to the N-O function.The reaction has been found to be first order in substrate when rates were measured in dioxane, and the activation parameters were calculated.The order of reactivity in this rearrangement is NO2 >> CN > COPh > COMe > COOEt > CONH2.The rates correlate very well with ?- constants and the ρ value was positive and large (+3.6) pointing to a highly po lar activated complex with an electron-rich reaction center.All results strongly support an intramolecular cyclic mechanism.

Mesogenic Esters of the 4-(Alkylpiperidino) Benzoic Acids

A number of alkyl and 4-substituted phenyl 4-(4-alkylpiperidino) benzoates have been prepared and their proprties examined.