220925-03-1

Basic information

• Product Name: (S)-2-fluorophenyl p-tolyl sulfoxide
• Synonyms: (S)-2-fluorophenyl p-tolyl sulfoxide
• CAS NO: 220925-03-1
• Molecular Weight: 234.294
• Mol File: 220925-03-1.mol

Chemical Properties

• CAS DataBase Reference: (S)-2-fluorophenyl p-tolyl sulfoxide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-fluorophenyl p-tolyl sulfoxide(220925-03-1)
• EPA Substance Registry System: (S)-2-fluorophenyl p-tolyl sulfoxide(220925-03-1)

Safety Data

• Hazardous Substances Data: 220925-03-1(Hazardous Substances Data)

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 1517-82-4 (1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate 

Downstream Products

• 220925-05-3 (S)-2-(diphenylphosphano)phenyl p-tolyl sulfoxide 

Relevant articles and documents

Chiral β-phosphino sulfoxides as chiral ligands in palladium-catalyzed asymmetric allylic nucleophilic substitution reactions

The first attempt to use chiral β-phosphino sulfoxides as chiral ligands was successfully accomplished in a palladium-catalyzed asymmetric allylic alkylation and amination, providing extremely high enantioselectivity with chiral 2-(diphenyl-phosphino)phenyl 2-methoxy-1-naphthyl sulfoxide. The structure of the intermediary palladium complex chelated by the ligand was determined by the X-ray crystallographic analysis. The mechanism for the asymmetric induction is proposed on the basis of the stereochemical results obtained.

New chiral sulfoxide ligands possessing a phosphano or phosphanoamino functionality in palladium-catalyzed asymmetric allylic nucleophilic substitution reactions

New chiral sulfoxide ligands possessing a phosphano or phosphanoamino functionality as an alternative coordinating element were developed, and their usefulness was demonstrated by applying them to palladium-catalyzed asymmetric allylic nucleophilic substitution reactions. The structure of the catalyst precursor coordinated by the chiral phosphino sulfoxide was determined by X-ray crystallographic analysis. The possible mechanism for the asymmetric induction using these chiral ligands was proposed on the basis of the stereochemical outcome obtained. (C) 2000 Elsevier Science Ltd.