220925-06-4

Upstream product

• 15475-27-1 potassium diphenylphosphine 
• 220925-04-2 (S)-2-fluorophenyl 2-methoxy-1-naphthyl sulfoxide 
• 155135-07-2 (-)-(1R,2S,5R)-menthyl (S)-2-methoxynaphthalene-1-sulfinate 
• 348-52-7 1-Fluoro-2-iodobenzene 

Relevant academic research and scientific papers

New chiral sulfoxide ligands possessing a phosphano or phosphanoamino functionality in palladium-catalyzed asymmetric allylic nucleophilic substitution reactions

New chiral sulfoxide ligands possessing a phosphano or phosphanoamino functionality as an alternative coordinating element were developed, and their usefulness was demonstrated by applying them to palladium-catalyzed asymmetric allylic nucleophilic substitution reactions. The structure of the catalyst precursor coordinated by the chiral phosphino sulfoxide was determined by X-ray crystallographic analysis. The possible mechanism for the asymmetric induction using these chiral ligands was proposed on the basis of the stereochemical outcome obtained. (C) 2000 Elsevier Science Ltd.

Chiral β-phosphino sulfoxides as chiral ligands in palladium-catalyzed asymmetric allylic nucleophilic substitution reactions

The first attempt to use chiral β-phosphino sulfoxides as chiral ligands was successfully accomplished in a palladium-catalyzed asymmetric allylic alkylation and amination, providing extremely high enantioselectivity with chiral 2-(diphenyl-phosphino)phenyl 2-methoxy-1-naphthyl sulfoxide. The structure of the intermediary palladium complex chelated by the ligand was determined by the X-ray crystallographic analysis. The mechanism for the asymmetric induction is proposed on the basis of the stereochemical results obtained.