220946-29-2Relevant academic research and scientific papers
Ring-opening of epoxyalcohols by diethylaluminium cyanide. Regio- and stereoselective synthesis of 1-cyano-2,3-diols
Benedetti, Fabio,Berti, Federico,Norbedo, Stefano
, p. 1041 - 1044 (1999)
Diethylaluminium cyanide is a highly selective reagent for the ring opening of 2,3-epoxyalcohols under mild conditions; the reaction takes place at C-3, with inversion of configuration, to give 1-cyano-2,3-diols.
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres via epoxyalcohols derived from α-amino acids
Benedetti, Fabio,Magnan, Monica,Miertus, Stanislav,Norbedo, Stefano,Parat, Djiana,Tossi, Alessandro
, p. 3027 - 3030 (2007/10/03)
(1R,2R,3S,4S)-4-Amino-3-hydroxy-1,2-epoxybutanes, accessible in four steps from L-aminoesters, react regio- and stereoselectively with diethyl aluminum cyanide to give (1R,2S,3S,4S)-4-amino-2,3-dihydroxynitriles. Hydrolysis yields hydroxylactones equivale
