Ring-opening of epoxyalcohols by diethylaluminium cyanide. Regio- and stereoselective synthesis of 1-cyano-2,3-diols

DOI: 10.1016/S0040-4039(98)02520-9

Source and publish data:

Tetrahedron Letters p. 1041 - 1044 (1999)

Update date:2022-08-03

Topics:

Authors:

Benedetti, Fabio

Berti, Federico

Norbedo, Stefano

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Article abstract of DOI:10.1016/S0040-4039(98)02520-9

Diethylaluminium cyanide is a highly selective reagent for the ring opening of 2,3-epoxyalcohols under mild conditions; the reaction takes place at C-3, with inversion of configuration, to give 1-cyano-2,3-diols.

Full text of DOI:10.1016/S0040-4039(98)02520-9

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