220953-69-5

Basic information

• Product Name: ANTALARMIN HYDROCHLORIDE
• Synonyms: ANTALARMIN HYDROCHLORIDE;N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride
• CAS NO: 220953-69-5
• Molecular Formula: C24H35ClN4
• Molecular Weight: 415.01
• Mol File: 220953-69-5.mol
• Article Data: 0

Chemical Properties

• Appearance: off-white/solid
• Storage Temp.: 2-8°C
• Solubility: DMSO: ~24 mg/mL, soluble
• CAS DataBase Reference: ANTALARMIN HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ANTALARMIN HYDROCHLORIDE(220953-69-5)
• EPA Substance Registry System: ANTALARMIN HYDROCHLORIDE(220953-69-5)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 220953-69-5(Hazardous Substances Data)

Usage

Description

Antalarmin hydrochloride, a selective nonpeptide antagonist of the CRH receptor 1 (Ki = 1 nM), is derived from the regulation of pituitary corticotropin-release and glucocorticoid secretion by Corticotropin-releasing hormone (CRH) secreted from the hypothalamus. It plays a crucial role in managing the release of corticotropin in response to chronic stress and has demonstrated potential in various therapeutic applications.

Uses

Used in Pharmaceutical Applications:
Antalarmin hydrochloride is used as a therapeutic agent for managing stress-related disorders. By antagonizing central CRH signaling, it helps reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli.
Used in Treatment of Cocaine Addiction:
Antalarmin hydrochloride is used as an addiction treatment agent, specifically for reducing dose escalation in cocaine-addicted rats. Its ability to modulate stress responses may contribute to its effectiveness in this application.
Used in Anti-inflammatory Applications:
Antalarmin hydrochloride is used as an anti-inflammatory agent, particularly in arthritis models. Its potential to suppress stress-induced inflammation makes it a promising candidate for treating inflammatory conditions.
Used in Gastrointestinal Applications:
Antalarmin hydrochloride is used as a treatment agent for stress-induced gastric ulceration related to irritable bowel syndrome. By mitigating the effects of stress on the gastrointestinal system, it can help in the management and healing of ulcers.

Biological Activity

Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.