220969-69-7

Basic information

• Product Name: 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester
• Synonyms: 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester
• CAS NO: 220969-69-7
• Molecular Weight: 261.321
• Mol File: 220969-69-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester(220969-69-7)
• EPA Substance Registry System: 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester(220969-69-7)

Safety Data

• Hazardous Substances Data: 220969-69-7(Hazardous Substances Data)

Upstream product

• 207554-16-3 4-(Benzyl-tert-butoxycarbonyl-amino)-3-oxo-butyric acid ethyl ester 
• 76315-01-0 N-benzyl-N-(tert-butoxycarbonyl)glycine 
• 207554-17-4 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester 

Downstream Products

• 144282-41-7 (S)-7-amino-5-benzyl-5-azaspiro[2.4]heptan-4-one 
• 180506-32-5 (R)-5-Benzyl-7-hydroxy-5-aza-spiro[2.4]heptan-4-one 
• 127199-45-5 (7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester 
• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 

Relevant articles and documents

An efficient synthesis of a key intermediate of DU-6859a via asymmetric microbial reduction

An efficient synthetic method for the C-7 substituent of DU-6859a (1), which is a new-generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial reduction of 5- benzyl-4,7-dioxo-5-azaspiro[2,4]heptane (7) to the corresponding chiral alcohol (8) as the key reaction. This synthetic method was based on use of AIPHOS (Artificial Intelligence for Planning and Handling Organic Synthesis), which is a synthesis design system that generates suitable retrosynthetic routes from the standpoints of both novelty and practicality.