129306-04-3

Usage

Uses

5-benzyl-5-azaspiro[2.4]heptane-4,7-dione is a useful research chemical.

Upstream product

• 32933-03-2 ethyl 1-acetylcyclopropanecarboxylate 
• 100-46-9 benzylamine 
• 129306-05-4 ethyl 1-(2-bromoacetyl)cyclopropanecarboxylate 
• 331443-52-8 N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide 
• 147011-39-0 1-acetyl-N-[benzyl]cyclopropane-1-carboxamide 
• 882-36-0 N-benzyl-3-oxobutanamide 
• 207554-17-4 1-[2-(Benzyl-tert-butoxycarbonyl-amino)-acetyl]-cyclopropanecarboxylic acid ethyl ester 
• 207554-16-3 4-(Benzyl-tert-butoxycarbonyl-amino)-3-oxo-butyric acid ethyl ester 
• 76315-01-0 N-benzyl-N-(tert-butoxycarbonyl)glycine 
• 220969-69-7 1-(2-Benzylamino-acetyl)-cyclopropanecarboxylic acid ethyl ester 

Downstream Products

• 180506-32-5 (R)-5-Benzyl-7-hydroxy-5-aza-spiro[2.4]heptan-4-one 
• 129306-06-5 4-oxo-5-benzyl-7-hydroxyimino-5-azaspiro[2,4]heptane 
• 144282-35-9 5-benzyl-7(S)-amino-5-azaspiro[2,4]heptane 
• 1432056-70-6 5-benzyl-7(S)-tert-butoxycarbonylamino-5-azaspiro[2,4]heptane 
• 944258-72-4 7-hydroxy-5-azaspiro[2.4]heptane 
• 152513-88-7 (7S)-5-aza-7-tert-butoxycarbonylaminospiro[2.4]heptan 
• 129306-13-4 5-phenylmethyl-N-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-7-amine 
• 129306-07-6 5-benzyl-5-azaspiro[2.4]heptane-7-amine 
• 129306-06-5 (7E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one 
• 1152111-03-9 (7Z)-5-phenylmethyl-5-azaspiro[2.4]heptane-4,7-dione 7-O-methyloxime 
• 129306-06-5 5-benzyl-7-(hydroxyimino)-4-oxo-5-azaspiro[2.4]heptane 
• 144282-41-7 (S)-7-amino-5-benzyl-5-azaspiro[2.4]heptan-4-one 
• 127199-45-5 (7S)-5-azaspiro[2.4]heptan-7-ylcarbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Having a spiro ring substituent of aryl morpholine compound, its preparation and use

The invention discloses arylmorpholine compounds with spiro substituents. The arylmorpholine compounds are compounds having the following general formula (I), wherein X is N or CH; R1 is hydrogen, hydroxyl, alkoxy, halogen, amino, amido, acylamino, sulfam

A 5-benzyl -7 (S)-tert-butoxycarbonylamino-5-azaspiro [2,4] heptane preparation method of

The invention discloses a preparation method for 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. The method comprises the following steps: reacting benzoylamide acetoacetate as a raw material with 1,2-dichloroethane to obtain 3-cyclopropyl benzoylamide acetoacetate, brominating 3-cyclopropyl benzoylamide acetoacetate by NBS (n-bromosuccinimide) to obtain 1-bromo-3-cyclopropyl benzoylamide acetoacetate, cyclizing under alkaline conditions to obtain 5-benzyl-5-aza-spiro[2,4]heptane-4,7-diketone, further reacting with hydroxylamine hydrochloride to form an oxime compound-4-oxo-5-benzyl-7-oximido-5-aza-spiro[2,4]heptane, reducing by NaBH4 and boron trifluoride diethyl etherate to obtain 5-benzyl-7-amino-5-aza-spiro[2,4]heptane, performing chiral resolution by a resolving agent-L-camphorsulfonic acid to obtain 5-benzyl-7(S)-amino-5-aza-spiro[2,4]heptane, and reacting with di-tert-butyl dicarbonate ester to obtain 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. According to the method, an intermediate body-carbonyl does not need protection, raw materials are easy to get, a process route is simple, and the method is suitable for industrial production.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I), wherein R1, R2 and R3 are defined herein and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

An efficient synthesis of a key intermediate of DU-6859a via asymmetric microbial reduction

An efficient synthetic method for the C-7 substituent of DU-6859a (1), which is a new-generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial reduction of 5- benzyl-4,7-dioxo-5-azaspiro[2,4]heptane (7) to the corresponding chiral alcohol (8) as the key reaction. This synthetic method was based on use of AIPHOS (Artificial Intelligence for Planning and Handling Organic Synthesis), which is a synthesis design system that generates suitable retrosynthetic routes from the standpoints of both novelty and practicality.

Spiro compound

The present invention relates to spiro compounds of general formula I: STR1 wherein the substituents are herein below defined. The present invention relates to antibacterial spiro compounds which are of value as drugs for humans, veterinary drugs or drugs for use in fish culture or as preservatives, and to antibacterial compositions containing one or more of the same compounds as active ingredients.