22098-62-0

Usage

Uses

Used in Pharmaceutical Industry:
(1H-IMIDAZOL-2-YL)-PHENYL-METHANOL is used as a pharmaceutical compound for its diverse biological activities. The imidazole ring within its structure is known to possess antifungal, antibacterial, and anti-inflammatory properties, making it a promising candidate for the development of new drugs targeting various health conditions.
Used in Drug Development:
(1H-IMIDAZOL-2-YL)-PHENYL-METHANOL is used as a building block for new drug candidates. The phenyl group in its structure can contribute to the compound's potential in forming novel drug molecules with improved therapeutic effects and reduced side effects.
Used in Organic Chemistry:
(1H-IMIDAZOL-2-YL)-PHENYL-METHANOL is used as a versatile chemical in organic synthesis reactions. The presence of the methanol group makes it a useful reactant in chemical processes, as methanol is a common solvent and reactant in the synthesis of various organic compounds.

Upstream product

• 38353-02-5 2-benzoylimidazole 
• 100-52-7 benzaldehyde 
• 61278-81-7 1-(diethoxymethyl)-1H-imidazole 
• 76100-32-8 2-Benzylimidazol-4,5-dicarbonsaeure 

Relevant academic research and scientific papers

1,2-functionalized imidazoles as palladium ligands: An efficient and robust catalytic system for the fluorine-free Hiyama reaction

A variety of hydroxy- and amino-functionalized imidazoles were prepared from 1-methyl- and 1-(diethoxymethyl)imidazole by means of isoprene-mediated lithiation followed by reaction with an electrophile. These compounds in combination with palladium acetate were screened as catalyst systems for the Hiyama reaction under fluorine-free conditions using microwave irradiation. The systematic study of the catalytic system showed 1-methyl-2-aminoalkylimidazole derivative L1 to be the best ligand, which was employed un-der solvent-free conditions with a 1:2 Pd/ligand ratio and TBAB (20 mol-%) as additive. The study has revealed an interaction between the Pd/ligand ratio and the amount of TBAB. The established catalytic system presented a certain degree of robustness, and it has been successfully employed in the coupling of a range of aryl bromides and chlorides with different aryl siloxanes. Furthermore, both reagents were employed in an equimolecular amount, without an excess of organosilane.

1,2-Functionalized Imidazoles as Palladium Ligands: An Efficient and Robust Catalytic System for the Fluorine-Free Hiyama Reaction

A variety of hydroxy- and amino-functionalized imidazoles were prepared from 1-methyl- and 1-(diethoxymethyl)imidazole by means of isoprene-mediated lithiation followed by reaction with an electrophile. These compounds in combination with palladium acetate were screened as catalyst systems for the Hiyama reaction under fluorine-free conditions using microwave irradiation. The systematic study of the catalytic system showed 1-methyl-2-aminoalkylimidazole derivative L1 to be the best ligand, which was employed under solvent-free conditions with a 1:2 Pd/ligand ratio and TBAB (20 mol-%) as additive. The study has revealed an interaction between the Pd/ligand ratio and the amount of TBAB. The established catalytic system presented a certain degree of robustness, and it has been successfully employed in the coupling of a range of aryl bromides and chlorides with different aryl siloxanes. Furthermore, both reagents were employed in an equimolecular amount, without an excess of organosilane.

Isoprene-catalysed lithiation: deprotection and functionalisation of imidazole derivatives

The isoprene-catalysed lithiation of different 1-substituted imidazoles (1) (such as trityl, allyl, benzyl, vinyl, N,N-dimethylsulfamoyl, para-toluenesulfonyl, tert-butoxycarbonyl, acetyl, trimethylsilyl, tert-butyldimethylsilyl derivatives) leads to the

An Easily Introduced and Removed Protecting Group for Imidazole Nitrogen: A Convenient Route to 2-Substituted Imidazoles

Orthoamides (3-5) prepared from imidazoles and triethyl or trimethyl orthoformate are rapidly metalated at -40 deg C in THF or ether to give the corresponding 2-lithio anion which reacts with a variety of electrophiles.The dialkoxymethyl protecting group is readily hydrolyzed under neutral or acidic conditions at room temperature, giving the 2-substituted 1H-imidazole 1 (R = H, X = COOH, n-C4H9, COCH3, CHOHC6H5, C(CH3)OH-2-pyridyl,9-hydroxyfluorenyl, 1-hydroxycyclohex-2-enyl, C(OH)(C6H5)2; R = CH3, R' = H, X = CHO) and the tris(2-imidazolyl)phosphines (R = H, CH3, CH(CH3)2).A mechanism for the deprotection of 3 is proposed.