220986-40-3

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 
• 2972-76-1 2-(2,4-dichlorobenzylidene)malononitrile 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Zn(L-proline)2 as an efficient and reusable catalyst for the multi-component synthesis of pyran-annulated heterocyclic compounds

We have developed a simple, straightforward and highly efficient multi-component one-pot synthesis of 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocyclic compounds. Zn(L-proline)2 has been utilized as a mild and efficient Lewis acid cata

1H-imidazol-3-ium tricyanomethanide {[HIM]C(CN)3} as a nanostructured molten salt catalyst: application to the synthesis of pyrano[4,3‐b]pyrans

In this work, we have synthesized a novel nanostructured molten salt, 1H-imidazol-3-ium tricyanomethanide {[HIMI]C(CN)3} (1), as an efficient and green protocol-compatible catalyst. This new molten salt has been fully characterized b

Synthesis and characterization of novel magnetic nanoparticles supported imidazole ion as an efficient catalytic system for the three-component reaction of arylaldehydes, malononitrile and a-hydroxy or a-amino active methylene compounds

Background: Recently, pyrimidine and chromene derivatives have concerned increasing attention because of the wide range of biological activities. Considering the prominence of pyrimidine and chromene derivatives, several procedures have been reported for the synthesis of these compounds. Herein, new magnetic nanoparticles supported ionic liquid has been evaluated for the synthesis of pyrimidine and chromene derivatives. Methods: In this method, pyrimidine and chromene compounds were synthesized by the multi-component reaction of aromatic aldehydes, malononitrile, and active methylene compounds in the presence of the new magnetic nanoparticles supported ionic liquid. The new nanocatalyst was characterized by using TEM, VSM, XRD and IR spectrum. Results: The remarkable advantages of this new procedure involve high yields, short experimental time, low cast and easy preparation of the catalyst and no need of any workup and purification. Magnetic properties of the catalyst led to the easy separation from the reaction mixture by using an external magnet. The catalyst can be reused several times in the desired reaction without significant decrease of its activity. Conclusion: An efficient and green method for the synthesis of chromene and pyrimidine compounds in the presence of magnetic nanoparticles supported ionic liquid have been developed. Thermal stability, low cost and easy synthesis of the catalyst, high yields, easy separation and purification of the product, short experimental time and using a green solvent such as water provided a useful and alternative method for such reactions.

Sodium ethylene diamine tetraacetate catalyzed synthesis of chromene derivatives via multi-component reactions at low catalyst loading

An efficient and practical protocol for the synthesis of chromenes derivatives catalyzed by a low-loading sodium ethylene diamine tetraacetate (2?mol%) as a catalyst via multicomponent reaction is reported. A wide range of aromatic aldehydes easily underg

Nano-cellulose-OSO3H as a new, green, and effective nano-catalyst for one-pot synthesis of pyrano [4,3-b] pyrans

A facile, green, and efficient method has been developed for the synthesis of biologically important pyrano [4,3-b] pyrans in the presence of nano-cellulose-OSO3H as a new solid acid catalyst. The reaction involves the use of 4-hydroxy-6-methyl

Method for preparing pyrano [4,3-b] pyran derivatives by basic ionic liquid catalysis

The invention discloses a method for preparing pyrano [4,3-b] pyran derivatives by basic ionic liquid catalysis, and belongs to the technical field of preparation of chemical materials. The molar ratio of aromatic aldehyde to 4-hydroxy-6-methylpyrane-2-ke

A facile and one-pot synthesis of pyrone derivatives via ionic liquid catalysed knoevenagel reaction and their biological evaluation

A series of novel pyrone derivatives was synthesized by using a green chemistry approach i.e. by the use of an ionic liquid, 1-butyl-3-methylimidazolium bromide. The three component one-pot synthesis of pyrone involves the Knoevenagel condensation reactio

Crown ether complex cation ionic liquids (CECILs) as environmentally benign catalysts for three-component synthesis of 4,5-dihydropyrano[3,2-c]chromene and 4,5-dihydropyrano[4,3-b]pyran derivatives

Crown ether complex cation ionic liquids (CECILs) catalyze three-component reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin or 4-hydroxy-6-methylpyrone, in EtOH under reflux, for synthesis of 4,5-dihydropyrano[3,2-c]chromene and 4,5-di

Preparation and characterization of nano-CaO based on eggshell waste: Novel and green catalytic approach to highly efficient synthesis of pyrano[4,3-b]pyrans

A general and efficient catalytic system for Pd/C-catalyzed ligand-free aerobic Suzuki cross-coupling reactions was developed. The reaction tolerated a wide range of aryl bromides with a hydrophilic group or a hydrophobic group without any additives in wa

Solvent-free, green and efficient synthesis of pyrano[4, 3-b]pyrans by grinding and their biological evaluation as antitumor and antioxidant agents

A facile, green, and efficient method has been developed for the synthesis of pyrano[4, 3-b]pyrans via a one-pot reaction of aromatic aldehydes, malononitrile, and 4-hydroxy-6-methyl-pyran-2-one in the presence of ammonium acetate under solvent-free condi