2972-76-1

Usage

Uses

Used in Law Enforcement and Military Applications:
(2,4-dichlorobenzylidene)propanedinitrile is used as a crowd control agent for managing and dispersing crowds during riots, protests, and other situations where non-lethal force is required. Its irritating effects on the eyes, nose, throat, and skin make it an effective tool for law enforcement and military forces to maintain order and control.
Used in Chemical Weaponry:
(2,4-dichlorobenzylidene)propanedinitrile is also used in chemical weaponry as a non-lethal agent. Its ability to cause pain and discomfort without causing permanent harm makes it a preferred choice for situations where minimizing casualties is a priority.

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 109-77-3 malononitrile 
• 110-89-4 piperidine 
• 111-71-7 heptanal 
• 1777-82-8 (2,4-dichlorophenyl)methanol 

Downstream Products

• 220986-40-3 2-amino-7-methyl-5-oxo-4-(2,4-dichlorophenyl)-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile 
• 475995-39-2 4-amino-2-(p-anisyl)-6-(2,4-dichlorophenyl)-pyrimidine-5-carbonitrile 
• 582306-99-8 4-amino-6-(2,4-dichloro-phenyl)-2-(3-methoxy-phenyl)-pyrimidine-5-carbonitrile 
• 582292-91-9 2-amino-4-(2,4-dichloro-phenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridine-3-carbonitrile 
• 582292-90-8 2-amino-4-(2,4-dichloro-phenyl)-7-methoxy-5H-indeno[1,2-b]pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile

An uncatalyzed efficient synthesis of bioactive pyridine derivatives has been investigated for the first time by a three-component sequential multicomponent reaction tackled with aromatic aldehydes, malononitrile, and 1,3-indandione via Knoevenagel condensation followed by Michael addition. The difference between the domino multicomponent and sequential multicomponent reaction is emphasized by this methodology. The reaction proceeds at ambient temperature without frequently useful N-source like ammonium salt for the construction of N-heterocycles, which makes this protocol a novel synthetic route for the preparation of the indenopyridine skeleton.

Synthesis of novel 15-aryl-2,3,4,15-tetrahydrochromeno[2′,3′:4,5] pyrimido[6,1-b]quinazoline-1,9-diones

A new series of 15-aryl-2,3,4,15-tetrahydrochromeno[2′,3′:4,5]pyrimido[6,1-b]quinazoline-1,9-diones was synthesised by the cyclisation of methyl anthranilate with ethyl N-(3-cyano-5-oxo-4-aryl-5,6,7,8-tetrahydro-4H-chromen-2-yl)formimidate derivatives, wh

Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives

The activities of enzymes can be targeted in the treatment of some diseases. Recently, this strategy has been used frequently in the development of new drugs. Carbonic anhydrase isozymes (CA-I and CA-II) and acetylcholine esterase (AChE) are some of these

Size and function influence study on enhanced catalytic performance of a cooperative MOF for mild, green and fast C-C bond formation

Tuning of pore function and size (surface area) are two key factors that play important roles in the performance of metal-organic-frameworks (MOFs) as catalysts. The catalytic performance of two bulk and nanosized MOFs with different functional groups suc

Synthesis of novel ethyl 1-Aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5] pyrimido[6,1-b]quinazoline-2-carboxylate derivatives

In this paper, a new series of ethyl 1-Aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5]pyrimido[6,1-b]quinazoline-2-carboxylate derivatives was synthesised by the cyclisation of methyl anthranilate with ethyl 5-cyano-6-[(ethoxymethylene)amino]-2-methyl-4-

Supported copper on a diamide-diacid-bridged PMO: an efficient hybrid catalyst for the cascade oxidation of benzyl alcohols/Knoevenagel condensation

In this study, a novel periodic mesoporous organosilica (PMO) containing diamide-diacid bridges was conveniently prepared using ethylenediaminetetraacetic dianhydride to support Cu(ii) species and affording supramolecular Cu@EDTAD-PMO nanoparticles efficiently. Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET) analysis, and high-resolution transmission electron microscopy (HRTEM) results confirmed the successful synthesis of Cu@EDTAD-PMO. The stabilized Cu(ii) nanoparticles inside the mesochannels of the new PMO provided appropriate sites for selective oxidation of different benzyl alcohol derivatives to their corresponding benzaldehydes and subsequent Knoevenagel condensation with malononitrile. Therefore, Cu@EDTAD-PMO can be considered as a multifunctional heterogeneous catalyst, which is prepared easily through a green procedure and demonstrates appropriate stability with almost no leaching of the Cu(ii) nanoparticles into the reaction medium, and easy recovery through simple filtration. The recycled Cu@EDTAD-PMO was reused up to five times without significant loss of its catalytic activity. The stability, recoverability, and reusability of the designed heterogeneous catalyst were also studied under various reaction conditions.

A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation

A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile derivatives (C1-C12) is proposed. Characterization of the derivatives was done by sup

Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation

Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of

Pseudo-Five-Component Stereoselective Synthesis of Highly Functionalized 3-Azabicyclo[3.3.1]nona-2,7-dienes

Abstract: The reaction of aromatic aldehydes with malononitrile, ethyl or butyl cyanoacetate and acetylacetone in the presence of NaOH under mild conditions (EtOH, 25°C) led to the formation of new series of (1S,5R,6R,9R)/(1R,5S,6S,9S)-2-amino-6,9-diaryl-

Synthesis of 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes from the same reactants by using metal-free catalyst

A facile and rapid multicomponent synthesis of pharmaceutically diverse 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes has been developed from benzaldehyde, malononitrile, and cyclohexanone. Three different methods from the same reactants, solvent, temperature, and catalyst lead to three products with excellent yields. All the reactions were followed with the Michael addition and cyclization. In this study, morpholine was used as an active metal-free base catalyst that increases the yields of products and decreases the time of reactions.