2972-76-1

Basic information

• Product Name: (2,4-dichlorobenzylidene)propanedinitrile
• CAS NO: 2972-76-1
• Molecular Formula: C₁₀H₄Cl₂N₂
• Molecular Weight: 223.0582
• Mol File: 2972-76-1.mol
• Article Data: 63

Chemical Properties

• Boiling Point: 368.6°C at 760 mmHg
• Flash Point: 166.2°C
• Density: 1.417g/cm³
• Vapor Pressure: 1.26E-05mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: (2,4-dichlorobenzylidene)propanedinitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-dichlorobenzylidene)propanedinitrile(2972-76-1)
• EPA Substance Registry System: (2,4-dichlorobenzylidene)propanedinitrile(2972-76-1)

Safety Data

• Hazardous Substances Data: 2972-76-1(Hazardous Substances Data)

Usage

General Description

(2,4-dichlorobenzylidene)propanedinitrile, also known as CS, is a potent tear gas and riot control agent primarily used by law enforcement and military forces for crowd control. It is a crystalline solid that is usually dispersed in the form of aerosol gas, causing irritation and burning sensations in the eyes, nose, throat, and skin upon exposure. CS works by stimulating pain-sensitive nerve endings and can also lead to respiratory distress and other systemic effects if inhaled in high concentrations. It is considered a non-lethal chemical weapon, but its use has been controversial due to potential long-term health effects and the risk of exacerbating existing medical conditions in individuals exposed to it.

Upstream product

• 109-77-3 malononitrile 
• 1777-82-8 (2,4-dichlorophenyl)methanol 
• 111-71-7 heptanal 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 110-89-4 piperidine 

Downstream Products

• 582306-99-8 4-amino-6-(2,4-dichloro-phenyl)-2-(3-methoxy-phenyl)-pyrimidine-5-carbonitrile 
• 582292-91-9 2-amino-4-(2,4-dichloro-phenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridine-3-carbonitrile 
• 737765-03-6 4-amino-6-(2,4-dichlorophenyl)-2-(methylthio)pyrimidine-5-carbonitrile 
• 582292-89-5 2-amino-4-(2,4-dichloro-phenyl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]pyridine-3-carbonitrile 
• 144036-33-9 2-amino-4-(2,4-dichlorophenyl)-5,6,7,8-tetrahydro-7,7-dimethyl-5-oxo-4H-chromene-3-carbonitrile 

Relevant articles and documents

Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile

An uncatalyzed efficient synthesis of bioactive pyridine derivatives has been investigated for the first time by a three-component sequential multicomponent reaction tackled with aromatic aldehydes, malononitrile, and 1,3-indandione via Knoevenagel condensation followed by Michael addition. The difference between the domino multicomponent and sequential multicomponent reaction is emphasized by this methodology. The reaction proceeds at ambient temperature without frequently useful N-source like ammonium salt for the construction of N-heterocycles, which makes this protocol a novel synthetic route for the preparation of the indenopyridine skeleton.

Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives

The activities of enzymes can be targeted in the treatment of some diseases. Recently, this strategy has been used frequently in the development of new drugs. Carbonic anhydrase isozymes (CA-I and CA-II) and acetylcholine esterase (AChE) are some of these

Synthesis of novel ethyl 1-Aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5] pyrimido[6,1-b]quinazoline-2-carboxylate derivatives

In this paper, a new series of ethyl 1-Aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5]pyrimido[6,1-b]quinazoline-2-carboxylate derivatives was synthesised by the cyclisation of methyl anthranilate with ethyl 5-cyano-6-[(ethoxymethylene)amino]-2-methyl-4-

Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation

Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of

Supported copper on a diamide-diacid-bridged PMO: an efficient hybrid catalyst for the cascade oxidation of benzyl alcohols/Knoevenagel condensation

In this study, a novel periodic mesoporous organosilica (PMO) containing diamide-diacid bridges was conveniently prepared using ethylenediaminetetraacetic dianhydride to support Cu(ii) species and affording supramolecular Cu@EDTAD-PMO nanoparticles efficiently. Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET) analysis, and high-resolution transmission electron microscopy (HRTEM) results confirmed the successful synthesis of Cu@EDTAD-PMO. The stabilized Cu(ii) nanoparticles inside the mesochannels of the new PMO provided appropriate sites for selective oxidation of different benzyl alcohol derivatives to their corresponding benzaldehydes and subsequent Knoevenagel condensation with malononitrile. Therefore, Cu@EDTAD-PMO can be considered as a multifunctional heterogeneous catalyst, which is prepared easily through a green procedure and demonstrates appropriate stability with almost no leaching of the Cu(ii) nanoparticles into the reaction medium, and easy recovery through simple filtration. The recycled Cu@EDTAD-PMO was reused up to five times without significant loss of its catalytic activity. The stability, recoverability, and reusability of the designed heterogeneous catalyst were also studied under various reaction conditions.