220992-47-2

Usage

Uses

Used in Pharmaceutical Industry:
7-chlorofuro[3,2-b]pyridine-2-carbonitrile is used as a pharmaceutical intermediate for its potential to contribute to the development of new drugs. Its heterocyclic structure allows for the creation of molecules with specific biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 7-chlorofuro[3,2-b]pyridine-2-carbonitrile is utilized as a precursor in the synthesis of agrochemicals. Its unique molecular structure can be harnessed to produce compounds with pesticidal or herbicidal properties, contributing to crop protection and yield enhancement.
Used in Organic Synthesis:
7-chlorofuro[3,2-b]pyridine-2-carbonitrile is used as a building block in organic synthesis for creating a variety of complex organic molecules. Its presence in the molecular structure can facilitate the formation of new compounds with diverse applications in chemistry and related fields.

Upstream product

• 220992-25-6 4-oxy-furo[3,2-b]pyridine-2-carbonitrile 
• 112372-11-9 2-cyanofuro<3,2-b>pyridine 
• 6602-32-0 2-bromo-pyridin-3-ol 
• 111079-44-8 2-trimethylsilylfuro<3,2-b>pyridine 
• 1071540-49-2 2-(trimethylsilanyl)furo[3,2-b]pyridine 4-oxide 
• 1071540-51-6 7-chloro-2-(trimethylsilanyl)furo[3,2-b]pyridine 
• 1071540-54-9 7-chloro-2-iodofuro[3,2-b]pyridine 

Relevant academic research and scientific papers

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Furopyridines. XXVII. Reactions of 2-methyl and 2-cyano derivatives of furo[2,3-b]-, -[3,2-b]-, - [2,3-c]- and -[3,2-c]pyridine

Bromination of 2-methylfuropyridines 1a-d-Me gave the 3-bromo derivatives 2a-d, while the 2-cyano compounds 1a-d-CN resulted in the recovery of the starting compounds. Nitration of 1a-d-Me and 1a-d-CN did not yield the corresponding nitro derivative, except for 1-c-CN giving 3-nitro derivative 3c in 7% yield. N-Oxidation of 1a-d-Me and 1b-d-CN with m- chloroperbenzoic acid yielded the N-oxides 4a-d-Me and 4b-d-CN, whereas 1a- CN did not afford the N-oxide. Cyanation of N-oxides 4a-d-Me and 4b-d-CN with trimethylsilyl cyanide gave the corresponding α-cyanopyridine compounds 5a- d-Me and 5b-d-CN. Chlorination of 4a-d-Me and 4b-d-CN with phosphorus oxychloride also gave the α-chloropyridine compounds 6b-d-Me and 6b-d-CN, accompanying formation of γ-chloropyridine 6a-Me, 6'b-Me and 6'b-CN, β- chloropyridine 6(b)-CN, and α'-chloropyridine derivatives 6'c-Me and 6'c- CN. Acetoxylation of 4a-d-Me and 4b-d-CN with acetic anhydride yielded α- acetoxypyridine compounds 7a-Me and 7b-CN, pyridone compounds 11d-Me, 11c-CN and 11d-CN, 3-acetoxy compounds 8, 9b, 9c, and 2-acetoxymethyl derivatives 10b and 10c.