22101-21-9Relevant academic research and scientific papers
Synthesis of acrylonitriles through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence
Hao, Lu,Wu, Feng,Ding, Zong-Cang,Xu, Su-Xia,Ma, Yan-Li,Chen, Li,Zhan, Zhuang-Ping
supporting information; experimental part, p. 6453 - 6456 (2012/06/15)
Nontoxic cyanide source: An unprecedented route to acrylonitriles by employing propargylic alcohols and para-tolylsulfonohydrazide as a combined cyano source has been developed (see scheme). This efficient and practical cyanation reaction proceeds through an FeCl3-catalyzed domino propargylic substitution/aza-Meyer-Schuster rearrangement sequence, the rearrangement process of which is reported for the first time. Copyright
A phosphane-free catalyst system for the heck arylation of disubstituted alkenes: Application to the synthesis of trisubstituted olefins
Guertler, Christoph,Buchwald, Stephen L.
, p. 3107 - 3112 (2007/10/03)
A new general procedure for the Heck arylation of disubstituted olefins is described. This procedure allows, in many instances, the stereoselective synthesis of trisubstituted olefins. Trisubstituted olefins are easily accessible under mild reaction condi
Role of water and phase transfer catalysts in the kinetics of condensation of diaryl ketones with acetonitrile initiated by solid potassium hydroxide
Bentley, T. William,Jones, Ray V. H.,Larder, Annette H.,Lock, Stephen J.
, p. 89 - 94 (2007/10/03)
The kinetics of reactions of benzophenone and substituted derivatives with acetonitrile in the presence of excess solid potassium hydroxide (KOH) to give 2,2-diarylacrylonitriles are reported. Reaction rates are strongly temperature dependent, and water,
Diphenylpropionic acids as new AT1 selective angiotensin II antagonists
Almansa, Carmen,Gómez, Luis A.,Cavalcanti, Fernando L.,De Arriba, Alberto F.,Rodríguez, Ricardo,Carceller, Elena,García-Rafanell, Julián,Forn, Javier
, p. 2197 - 2206 (2007/10/03)
The synthesis and pharmacological evaluation of a new series of potent AT1 selective diphenylpropionic acid nonpeptide angiotensin II receptor antagonists are reported. The new compounds were evaluated for in vitro AT1 (rat liver) an
