221057-89-2

Basic information

• Product Name: 1-(2-phenylethyl)-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine
• CAS NO: 221057-89-2
• Molecular Weight: 273.375
• Mol File: 221057-89-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-phenylethyl)-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-phenylethyl)-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine(221057-89-2)
• EPA Substance Registry System: 1-(2-phenylethyl)-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine(221057-89-2)

Safety Data

• Hazardous Substances Data: 221057-89-2(Hazardous Substances Data)

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 60553-33-5 4-(2-methyl-1,3-dioxolan-2-yl)pyridine 

Relevant articles and documents

Synthesis and in vivo and in vitro evaluation of isoarecolone and derivatives

The synthesis of the N-ethyl and N-phenylethyl derivatives of isoarecolone are described. These compounds were evaluated in vitro for their ability to displace [3H](±)epibatidine and/or [3H](-) nicotine from nicotinic receptors derived from rat cerebral cortex and their ability to inhibit acetylcholinesterase. The N-ethyl derivative and isoarecolone were evaluated in vivo for their antinociceptive, hypothermia and hypomotility activity in mice. The in vivo activity of isoareeolone was found to the reversible by mecamylamine, however the N-ethyl derivative was found to be insensitive to blockade by mecamylamine.