60553-33-5

Usage

InChI:InChI=1/C9H11NO2/c1-9(11-6-7-12-9)8-2-4-10-5-3-8/h2-5H,6-7H2,1H3

Upstream product

• 67828-88-0 4-acetylpyridine hydrochloride 
• 107-21-1 ethylene glycol 
• 1122-54-9 methyl (4-pyridyl) ketone 

Downstream Products

• 110377-09-8 1-(3,4-dimethoxy-phenethyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-pyridinium; bromide 
• 104642-54-8 1-(2,4-dinitrophenyl)-4-(2-methyl-1,3-dioxolan-2-yl)pyridinium chloride 
• 113707-46-3 3-<1-benzyl-4-<1,1-(ethylenedioxy)ethyl>-1,2,3,6-tetrahydro-2-pyridyl>-1-(phenylsulfonyl)indole 
• 113707-44-1 3-<1-benzyl-4-<1,1-(ethylenedioxy)ethyl>-1,2,3,6-tetrahydro-2-pyridyl>indole 
• 113707-40-7 1-benzyl-4-<1,1-(ethylenedioxy)ethyl>-1,2,3,6-tetrahydropyridine-2-carbonitrile 
• 113707-37-2 4-acetyl-1-benzyl-1,2,3,6-tetrahydropyridine 
• 221057-89-2 1-(2-phenylethyl)-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine 
• 60553-32-4 1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 113707-39-4 1-benzyl-4-<1,1-(ethylenedioxy)ethyl>pyridinium chloride 
• 31271-21-3 1-benzyl-4-(2-methyl-[1,3]dioxolan-2-yl)-1H-pyridin-2-one 

Relevant academic research and scientific papers

SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS

Disclosed herein are compounds that selectively bind an expanded transcribed repeat r(G4C2)exp, prevent sequestration of RNA-binding proteins, and inhibit translation of repeat associated non-ATG (RAN) translation responsible for generation of toxic dipeptide repeats underlying diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The compounds and their pharmaceutical compositions are useful in treating a disease or condition characterized by an expanded G4C2 repeat RNA (r(G4C2)exp), such as ALS and FTD.

Synthesis and in vivo and in vitro evaluation of isoarecolone and derivatives

The synthesis of the N-ethyl and N-phenylethyl derivatives of isoarecolone are described. These compounds were evaluated in vitro for their ability to displace [3H](±)epibatidine and/or [3H](-) nicotine from nicotinic receptors derived from rat cerebral cortex and their ability to inhibit acetylcholinesterase. The N-ethyl derivative and isoarecolone were evaluated in vivo for their antinociceptive, hypothermia and hypomotility activity in mice. The in vivo activity of isoareeolone was found to the reversible by mecamylamine, however the N-ethyl derivative was found to be insensitive to blockade by mecamylamine.

An Improved Synthesis of 1-(1,2,3,6-Tetrahydro-1-methyl-4- Pyridinyl)ethanone, Isoarecolone

A convenient synthesis of 1-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)ethanone, isoarecolone, starting with 4-acetylpyridine is presented. 4-Acetylpyridine was protected as the ketal followed by reaction with iodomethane to give the quaterary salt. The quaterary salt was reduced with sodium borohydride followed by deprotection to give isoarecolone in 80% overall yield.