60553-33-5

Basic information

• Product Name: 4-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE
• Synonyms: 4-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE
• CAS NO: 60553-33-5
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 60553-33-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 260.7°C at 760 mmHg
• Flash Point: 95.5°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 0.0195mmHg at 25°C
• Refractive Index: 1.514
• PKA: 4.86±0.10(Predicted)
• CAS DataBase Reference: 4-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(60553-33-5)
• EPA Substance Registry System: 4-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(60553-33-5)

Safety Data

• Hazardous Substances Data: 60553-33-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-9(11-6-7-12-9)8-2-4-10-5-3-8/h2-5H,6-7H2,1H3

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 107-21-1 ethylene glycol 
• 67828-88-0 4-acetylpyridine hydrochloride 

Downstream Products

• 60553-32-4 1-methyl-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine 
• 221057-89-2 1-(2-phenylethyl)-4-(2-methyl-1,3-dioxolan-2-yl)-1,2,3,6-tetrahydropyridine 
• 113707-37-2 4-acetyl-1-benzyl-1,2,3,6-tetrahydropyridine 
• 113707-40-7 1-benzyl-4-<1,1-(ethylenedioxy)ethyl>-1,2,3,6-tetrahydropyridine-2-carbonitrile 
• 113707-44-1 3-<1-benzyl-4-<1,1-(ethylenedioxy)ethyl>-1,2,3,6-tetrahydro-2-pyridyl>indole 
• 113707-46-3 3-<1-benzyl-4-<1,1-(ethylenedioxy)ethyl>-1,2,3,6-tetrahydro-2-pyridyl>-1-(phenylsulfonyl)indole 
• 104642-54-8 1-(2,4-dinitrophenyl)-4-(2-methyl-1,3-dioxolan-2-yl)pyridinium chloride 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 113707-39-4 1-benzyl-4-<1,1-(ethylenedioxy)ethyl>pyridinium chloride 
• 31271-21-3 1-benzyl-4-(2-methyl-[1,3]dioxolan-2-yl)-1H-pyridin-2-one 
• 110377-09-8 1-(3,4-dimethoxy-phenethyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-pyridinium; bromide 

Relevant articles and documents

SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS

Disclosed herein are compounds that selectively bind an expanded transcribed repeat r(G4C2)exp, prevent sequestration of RNA-binding proteins, and inhibit translation of repeat associated non-ATG (RAN) translation responsible for generation of toxic dipeptide repeats underlying diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The compounds and their pharmaceutical compositions are useful in treating a disease or condition characterized by an expanded G4C2 repeat RNA (r(G4C2)exp), such as ALS and FTD.

An Improved Synthesis of 1-(1,2,3,6-Tetrahydro-1-methyl-4- Pyridinyl)ethanone, Isoarecolone

A convenient synthesis of 1-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)ethanone, isoarecolone, starting with 4-acetylpyridine is presented. 4-Acetylpyridine was protected as the ketal followed by reaction with iodomethane to give the quaterary salt. The quaterary salt was reduced with sodium borohydride followed by deprotection to give isoarecolone in 80% overall yield.