221069-48-3Relevant academic research and scientific papers
Enzymatic procedure catalysed by lipase from Candida antarctica for the regioprotection-deprotection of glucosamine
Nicolosi, Giovanni,Spatafora, Carmela,Tringali, Corrado
, p. 2891 - 2897 (2007/10/03)
Both peracetyl α-glucosamine 3 and its β-epimer 4 undergo alcoholysis with butanol in THF, catalysed by lipase from Candida antarctica (Novozym 435) to afford the triester 6 and diester 9, respectively. Esterification of these compounds, using vinyl acetate in the presence of Novozym 435, gives the partial esters 10 and 11, bearing a deprotected hydroxyl function at C-4, ready for inversion of configuration to open a route in the preparation of galactosamine.
