221106-47-4Relevant academic research and scientific papers
Peptide based interleukin-1β converting enzyme (ICE) inhibitors: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex
Okamoto, Yoshinori,Anan, Hideki,Nakai, Eiichi,Morihira, Koichiro,Yonetoku, Yasuhiro,Kurihara, Hiroyuki,Sakashita, Hitoshi,Terai, Yoshiya,Takeuchi, Makoto,Shibanuma, Tadao,Isomura, Yasuo
, p. 11 - 21 (2007/10/03)
Based on the X-ray structure of the complex of Ac-Tyr-Val-Ala-Asp-H (L- 709049) and interleukin-1β converting enzyme (ICE), we synthesized compounds which were derived from 2-NapCO-Val-Pro-Asp-CH2OPh (1) to obtain a potent inhibitor in the cell
