221106-60-1Relevant articles and documents
Practical and efficient route to (S)-γ-fluoroleucine
Truong, Vouy Linh,Gauthier, Jacques Yves,Boyd, Michael,Roy, Bruno,Scheigetz, John
, p. 1279 - 1280 (2007/10/03)
A practical and efficient route to (S)-γ-fluoroleucine was developed via compound 9. Introduction of the fluorine was achieved using N,N-diethylaminosulfur trifluoride (DAST) treatment on a tertiary alcohol 8.
Peptide based interleukin-1β converting enzyme (ICE) inhibitors: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex
Okamoto, Yoshinori,Anan, Hideki,Nakai, Eiichi,Morihira, Koichiro,Yonetoku, Yasuhiro,Kurihara, Hiroyuki,Sakashita, Hitoshi,Terai, Yoshiya,Takeuchi, Makoto,Shibanuma, Tadao,Isomura, Yasuo
, p. 11 - 21 (2007/10/03)
Based on the X-ray structure of the complex of Ac-Tyr-Val-Ala-Asp-H (L- 709049) and interleukin-1β converting enzyme (ICE), we synthesized compounds which were derived from 2-NapCO-Val-Pro-Asp-CH2OPh (1) to obtain a potent inhibitor in the cell
