221121-26-2

Upstream product

• 1878-65-5 3-chlorophenylacetic acid 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 252669-21-9 N-methoxy-N-methyl-2-(3-chlorophenyl)acetamide 
• 2593-90-0 2-(3-chlorophenyl)acetyl hydroxamic acid 
• 221121-57-9 6-(3-chloro-benzyl)-5-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 221121-50-2 6-(3-chloro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 491612-24-9 1-(3-chloro-phenyl)-3-nitro-propan-2-one 
• 221122-22-1 4-(3-chlorophenyl)-3-oxobutyric acid ethyl ester 

Relevant academic research and scientific papers

An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives

An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high-energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. (Figure presented.).

Kinetic and thermodynamic acidities of substituted 1-benzyl-1-methoxy-2-nitroethylenes. Strong reduction of the transition state imbalance compared to other nitroalkanes

Acidity constants of six substituted 1-benzyl-1-methoxy-2-nitroethylenes (2-Z with Z = m-NO2, m-CF3, m-Cl, H, p-Me, p-MeO) and their respective nitronic acids were determined in 50% DMSO-50% water (v/v) at 20 °C. Kinetic data were ob