221121-36-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of pharmaceutical compounds. Its role as a precursor in the biosynthesis of GABA makes it a valuable component in the development of drugs targeting the central nervous system.
Used in Agricultural Industry:
In the agricultural sector, 4-(3-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER is utilized as a building block for the synthesis of agrochemicals. Its application aids in the development of new pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Organic Synthesis:
4-(3-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER is used as a reagent in organic synthesis to produce new chemical compounds. Its versatility allows for the creation of a wide range of products for various applications in both the pharmaceutical and agricultural industries.

InChI:InChI=1/C12H13FO3/c1-2-16-12(15)8-11(14)7-9-4-3-5-10(13)6-9/h3-6H,2,7-8H2,1H3

Upstream product

• 6148-64-7 ethyl potassium malonate 
• 221121-29-5 2-(3-Fluoro-phenyl)-1-imidazol-1-yl-ethanone 
• 2033-24-1 cycl-isopropylidene malonate 
• 64-17-5 ethanol 
• 458-04-8 3-fluorophenylacetyl chloride 
• 331-25-9 (3-fluorophenyl)acetic acid 

Downstream Products

• 221121-53-5 6-(3-fluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 1159576-78-9 ethyl (2Z)-3-amino-4-(3-fluorophenyl)but-2-enoate 

Relevant academic research and scientific papers

Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation

Axl has emerged as an attractive target for cancer therapy due to its strong correlation with tumor growth, metastasis, poor survival, and drug resistance. Herein, we report the design, synthesis and structure-activity relationship (SAR) investigation of a series of pyrrolo[2,3-d]pyrimidine derivatives as new Axl inhibitors. Among them, the most promising compound 13b showed high enzymatic and cellular Axl potencies. Furthermore, 13b possessed preferable pharmacokinetic properties and displayed promising therapeutic effect in BaF3/TEL-Axl xenograft tumor model. Compound 13b may serve as a lead compound for new antitumor drug discovery.

MACROCYCLIC INDOLES AS MCL-1 INHIBITORS

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L1, L2, L3, ?, ?, ? are as defined as set forth in the specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS

Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R 1a, R 1b, L 1, L 2, L 3, X, A, B and C are as defined as set forth

Big ring indole used as MCL-1 inhibitor

The invention provides a compound represented by a formula (I) and a pharmaceutical salt and solvate thereof. In the formula (I), the definitions of R, R1a, R1b, R1h, L1, L2, and L3 are shown in the description. The invention also provides a compound represented by the formula (I), and the compound can be used to treat disease or disorder related with MCL-1 inhibition, such as cancers.

5-alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin- 4(3H)-ones: Novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives

Molecular modeling analysis of compounds belonging to the recently published series of dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S- DABOs and DATNOs, gave support to the design of new 2,6-disubstituted benzyl- DABO derivatives as highly potent