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3-Fluorophenylacetyl chloride, with the molecular formula C8H7ClF, is a colorless to pale yellow liquid chemical compound. It is recognized for its high reactivity as an acylating agent, which allows it to engage in reactions with nucleophiles to produce a diverse range of organic compounds. This characteristic makes it a valuable building block in the synthesis of pharmaceuticals and agrochemicals, as well as an intermediate in the production of dyes, pigments, and other fine chemicals. Due to its strong irritant properties to the eyes, skin, and respiratory system, it requires careful handling in well-ventilated areas with proper personal protective equipment.

458-04-8

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458-04-8 Usage

Uses

Used in Pharmaceutical Industry:
3-Fluorophenylacetyl chloride is used as a building block for the synthesis of various pharmaceuticals, leveraging its reactivity to form complex organic compounds that can exhibit therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluorophenylacetyl chloride serves as a key intermediate in the creation of compounds designed to protect crops and enhance agricultural productivity.
Used in Dye and Pigment Manufacturing:
3-Fluorophenylacetyl chloride is utilized as an intermediate in the production of dyes and pigments, contributing to the development of colorants for a variety of applications.
Used in Fine Chemicals Production:
3-FLUOROPHENYLACETYL CHLORIDE is also employed in the manufacturing of other fine chemicals, where its reactive nature is harnessed to produce specialty chemicals for specific industrial uses.
Each application takes advantage of 3-Fluorophenylacetyl chloride's unique chemical properties to fulfill the requirements of different industries, underscoring its versatility and importance in chemical synthesis and compound development.

Check Digit Verification of cas no

The CAS Registry Mumber 458-04-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 458-04:
(5*4)+(4*5)+(3*8)+(2*0)+(1*4)=68
68 % 10 = 8
So 458-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClFO/c9-8(11)5-6-2-1-3-7(10)4-6/h1-4H,5H2

458-04-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(3-fluorophenyl)acetyl chloride

1.2 Other means of identification

Product number -
Other names 3-fluorophenylacetic acid chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:458-04-8 SDS

458-04-8Relevant academic research and scientific papers

N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES

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Page/Page column 80; sheet 4, (2010/08/08)

This invention provides thiazolylpiperazine derivatives, and N-sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, which are useful active ingredients for administration in a method for the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides methods for making such derivatives, and pharmaceutical compositions including such derivatives together with pharmaceutically acceptable excipients.

SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE

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Page/Page column 29, (2010/09/17)

The present application discloses novel substituted 1,4-oxazepanyl-pyridine derivatives and their use as modulators of the voltage gated KV7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, i

PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES

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Page/Page column 92, (2008/06/13)

The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Formula (I)

SUBSTITUTED MORPHOLINE AND THIOMORPHOLINE DERIVATIVES

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Page/Page column 50, (2008/06/13)

The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.

, p. 1723 - 1727 (2007/10/03)

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

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