458-04-8

Basic information

• Product Name: 3-FLUOROPHENYLACETYL CHLORIDE
• Synonyms: 3-FLUOROPHENYLACETYL CHLORIDE;Between fluorobenzene chloride;2-(3-Fluorophenyl)ethanoyl chloride;3-Fluorophenylacetyl chloride 97+%;Benzeneacetyl chloride,3-fluoro-;Acetylchloride, (m-fluorophenyl)- (8CI);3-Fluorophenylace...
• CAS NO: 458-04-8
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• Mol File: 458-04-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 217.2°C at 760 mmHg
• Flash Point: 85.1°C
• Appearance: /
• Density: 1.278g/cm³
• Vapor Pressure: 0.135mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 3-FLUOROPHENYLACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROPHENYLACETYL CHLORIDE(458-04-8)
• EPA Substance Registry System: 3-FLUOROPHENYLACETYL CHLORIDE(458-04-8)

Safety Data

• Hazardous Substances Data: 458-04-8(Hazardous Substances Data)

Usage

General Description

3-Fluorophenylacetyl chloride is a chemical compound with the molecular formula C8H7ClF. It is a colorless to pale yellow liquid that is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. 3-FLUOROPHENYLACETYL CHLORIDE is a highly reactive acylating agent, capable of reacting with nucleophiles to form a wide variety of organic compounds. It is also used as an intermediate in the manufacturing of dyes, pigments, and other fine chemicals. 3-Fluorophenylacetyl chloride is known to be a strong irritant to the eyes, skin, and respiratory system, and should be handled with caution in a well-ventilated area with appropriate personal protective equipment.

InChI:InChI=1/C8H6ClFO/c9-8(11)5-6-2-1-3-7(10)4-6/h1-4H,5H2

Upstream product

• 455-38-9 3-fluorobenzoic acid 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 352-70-5 m-Fluorotoluene 
• 501-00-8 3-fluorophenylacetonitrile 
• 1711-07-5 3-fluorobenzoyl chloride 
• 6929-49-3 m-Fluoro-ω-diazoacetophenon 

Downstream Products

• 2711-92-4 (3-fluoro-phenyl)-acetic acid-(2-piperidino-ethyl ester) 
• 29419-15-6 7-fluoro-1,2,3,4-tetrahydronaphthalen-2-one 
• 548771-68-2 5-fluoro-2-tetralone 
• 143659-28-3 1-Naphthylmethyl 3-fluorophenylacetate 
• 423184-26-3 1-diazo-3-(3-fluoro-phenyl)-propan-2-one 
• 423184-31-0 1-bromo-3-(3-fluorophenyl)-propan-2-one 
• 423184-49-0 2-(3-fluorophenylmethyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one 
• 1211978-41-4 C₁₆H₁₁FO₂ 
• 1403776-43-1 C₁₉H₁₅F₂N₃O₂ 
• 1094313-25-3 1-(4-chlorophenyl)-2-(3-fluorophenyl)ethan-1-one 

Relevant articles and documents

N-SULFONYL THIAZOLYLPIPERAZINE DERIVATIVES AND RELATED N-SULFONYL HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES

This invention provides thiazolylpiperazine derivatives, and N-sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, which are useful active ingredients for administration in a method for the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides methods for making such derivatives, and pharmaceutical compositions including such derivatives together with pharmaceutically acceptable excipients.

PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES

The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Formula (I)

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.