221121-43-3Relevant articles and documents
Synthesis and biological evaluation of novel anti-hepatitis C virus (HCV) agents: 2-hydroxylphenethyl sulfanyl-oxopyrimidines
Wu, Daochun,Feng, Yue,Wang, Hua,Yang, Junfeng,Chen, Xian,Wang, Yueping,Cong Lai, Christopher,Zhang, Yufang,Li, Cong,Xia, Xueshan,He, Yanping
, p. 1388 - 1396 (2017/06/05)
A novel series of dihydro-hydroxyl-phene-thylsulfanyl-ω-cyclohexyl/phenyl-oxopyrimidine derivatives have been synthesized and their in vitro anti-hepatitis C virus activities have been evaluated using Huh 7.5.1 cells. Some of the compounds showed moderate
Solution-phase parallel synthesis of S-DABO analogues
Togninelli, Andrea,Carmi, Caterina,Petricci, Elena,Mugnaini, Claudia,Massa, Silvio,Corelli, Federico,Botta, Maurizio
, p. 65 - 67 (2007/10/03)
A simple and straightforward methodology for the parallel, solution-phase synthesis of a new series of S-DABO derivatives 1 and 2, bearing aromatic substituents at the C2 and C6 positions, has been developed. Starting from potassium ethyl malonates 3, thi
Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity
Manetti, Fabrizio,Esté, José A.,Clotet-Codina, Imma,Armand-Ugón, Mercedes,Maga, Giovanni,Crespan, Emmanuele,Cancio, Reynel,Mugnaini, Claudia,Bernardini, Cesare,Togninelli, Andrea,Carmi, Caterina,Alongi, Maddalena,Petricci, Elena,Massa, Silvio,Corelli, Federico,Botta, Maurizio
, p. 8000 - 8008 (2007/10/03)
A simple and efficient methodology for the parallel solution-phase synthesis has been set up to obtain a series of thiouracils, in turn selectively S-benzylated under microwave irradiation to give new S-DABOs. Biological screening led to the identificatio
5-alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin- 4(3H)-ones: Novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives
Mai, Antonello,Artico, Marino,Sbardella, Gianluca,Massa, Silvio,Novellino, Ettore,Greco, Giovanni,Loi, Anna Giulia,Tramontano, Enzo,Marongiu, Maria Elena,La Colla, Paolo
, p. 619 - 627 (2007/10/03)
Molecular modeling analysis of compounds belonging to the recently published series of dihydro-alkoxy-benzyl-oxopyrimidines (DABOs), such as S- DABOs and DATNOs, gave support to the design of new 2,6-disubstituted benzyl- DABO derivatives as highly potent