221129-37-9Relevant academic research and scientific papers
Metalation of 3-trimethylsilyl propargyl chloride: A stereoselective access to trans-propargylic oxiranes
Chemla, Fabrice,Bernard, Nicolas,Normant, Jean F.
, p. 75 - 78 (1999)
The metalation of 3-trimethylsilyl-1-chloroprop-2-yne and the subsequent reaction with aldehydes affords stereospecifically anti-chlorohydrins which give after treatment with potassium fluoride and NaOH propargylic epoxides with good to excellent yields.
Preparation of propargylic carbenoids and reactions with carbonyl compounds - A stereoselective synthesis of propargylic halohydrins and oxiranes
Chemla, Fabrice,Bernard, Nicolas,Ferreira, Franck,Normant, Jean F.
, p. 3295 - 3300 (2007/10/03)
The preparation and the reactivity of the zincioallene 3 is described, This organometallic compound reacts with aldehydes to yield propargylic halohydrins with good diastereoselectivities. These halohydrins can easily be converted into propargylic oxirane
