221129-99-3Relevant academic research and scientific papers
Nonenzymatic kinetic resolution of racemic α-hydroxyalkanephosphonates with chiral copper catalyst
Demizu, Yosuke,Moriyama, Atsushi,Onomura, Osamu
experimental part, p. 5241 - 5244 (2009/12/06)
Kinetic resolution of α-hydroxyalkanephosphonates was efficiently performed by benzoylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst with excellent s value of up to 286.
An efficient route to chiral α- and β-hydroxyalkanephosphonates
Pamies, Oscar,Baeckvall, Jan-E.
, p. 4815 - 4818 (2007/10/03)
Enzymatic kinetic resolution of α- and β-hydroxyphosphonates in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic hydroxyphosphonates were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and yield up to 87%).
