221136-66-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-6-methyl-2-oxo-1(2H)-pyrazineacetic acid ethyl ester is used as a building block for the synthesis of various drugs and pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new medications, contributing to the advancement of healthcare and treatment options.
Used in Agrochemical Production:
3-BROMO-6-METHYL-2-OXO-1(2H)-PYRAZINEACETIC ACID ETHYL ESTER also serves as an intermediate in the production of agrochemicals, playing a crucial role in the synthesis of pesticides, herbicides, and other agricultural chemicals. Its involvement in this industry helps to improve crop yields and protect plants from pests and diseases.
Used in Dye Manufacturing:
3-Bromo-6-methyl-2-oxo-1(2H)-pyrazineacetic acid ethyl ester is utilized as an intermediate in the manufacturing of dyes, contributing to the creation of a wide range of colorants used in various industries such as textiles, plastics, and printing inks. Its presence in the dye industry enhances the colorfastness and vibrancy of the final products.

InChI:InChI=1/C9H11BrN2O3/c1-3-15-7(13)5-12-6(2)4-11-8(10)9(12)14/h4H,3,5H2,1-2H3

Upstream product

• 221136-61-4 3,4-dihydro-6-methyl-2,3-dioxo-1(2H)-pyrazineacetic acid ethyl ester 
• 221136-61-4 Ethyl (3-hydroxy-6-methyl-2-oxo-2H-pyrazin-1-yl)-acetate 
• 221136-54-5 [[1,2-dioxo-2-[(2-oxopropyl)amino]ethyl]amino]acetic acid ethyl ester 
• 221136-49-8 [[2-[(2-hydroxypropyl)amino]-1,2-dioxoethyl]amino]acetic acid ethyl ester 
• 29655-79-6 [(2-ethoxy-2-oxoethyl)amino]oxoacetic acid ethyl ester 

Downstream Products

• 298704-30-0 6-methyl-2-oxo-3-[(2-phenylethyl)amino]-1(2H)-pyrazineacetic acid ethyl ester 
• 221136-76-1 3-(2,2-Difluoro-2-phenylethylamino)-1-(ethoxycarbonylmethyl)-6-methylpyrazinone 
• 454483-59-1 C₂₇H₃₈N₆O₃SSi 

Relevant academic research and scientific papers

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.

Cyclic oxyguanidine pyrazinones as protease inhibitors

Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: wherein R3, R4, R5, W, and A are as set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:

Kilogram scale synthesis of the pyrazinone acetic acid core of an orally efficacious thrombin inhibitor

A multi-kilogram scale synthesis of the orally efficacious thrombin inhibitor 1 has been achieved via construction of the pyrazinone core from an unsymmetric oxalic diamide. Key features include judicious choice of reagents to minimize side products, a ke

Pyrazinone thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: for example: