221137-08-2Relevant academic research and scientific papers
Cycloadditions of noncomplementary substituted 1,2,3-triazines
Anderson, Erin D.,Duerfeldt, Adam S.,Zhu, Kaicheng,Glinkerman, Christopher M.,Boger, Dale L.
, p. 5084 - 5087 (2014)
The scope of the [4 + 2] cycloaddition reactions of substituted 1,2,3-triazines, bearing noncomplementary substitution with electron-withdrawing groups at C4 and/or C6, is described. The studies define key electronic and steric effects of substituents impacting the reactivity, mode (C4/N1 vs C5/N2), and regioselectivity of the cycloaddition reactions of 1,2,3-triazines with amidines, enamines, and ynamines, providing access to highly functionalized heterocycles.
