221165-76-0

Basic information

• Product Name: 7-(4-benzylcarbamoyloxymethyl-imidazol-1-yl)-3-oxo-6-trifluoromethyl-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester
• CAS NO: 221165-76-0
• Molecular Weight: 515.449
• Mol File: 221165-76-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-(4-benzylcarbamoyloxymethyl-imidazol-1-yl)-3-oxo-6-trifluoromethyl-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-benzylcarbamoyloxymethyl-imidazol-1-yl)-3-oxo-6-trifluoromethyl-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester(221165-76-0)
• EPA Substance Registry System: 7-(4-benzylcarbamoyloxymethyl-imidazol-1-yl)-3-oxo-6-trifluoromethyl-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester(221165-76-0)

Safety Data

• Hazardous Substances Data: 221165-76-0(Hazardous Substances Data)

Upstream product

• 3173-56-6 benzyl isothiocyanate 
• 221164-26-7 ethyl 3,4-dihydro-7-[4-(hydroxymethyl)imidazol-1-yl]-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate 
• 791823-71-7 N-[4-(4-hydroxymethyl-imidazol-1-yl)-2-nitro-5-trifluoromethyl-phenyl]-N-(4-methoxy-benzyl)-acetamide 
• 221167-32-4 4-[4-(hydroxymethyl)imidazol-1-yl]-2-nitro-5-(trifluoromethyl)aniline 
• 221167-34-6 4-[4-(hydroxymethyl)imidazol-1-yl]-5-(trifluoromethyl)-1,2-phenylenediamine 
• 143151-01-3 4-fluoro-2-nitro-5-(trifluoromethyl)acetanilide 
• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 
• 2145-38-2 4-fluoro-3-(trifluoromethyl)acetanilide 
• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 

Relevant articles and documents

Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group

We describe the synthesis, physicochemical and biological properties of a novel series of 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acids with a substituted phenyl group. Among them, compound 9k (KRP-199) was found to possess high potency and selectivity for the AMPA-R and to exhibit good neuroprotective effects in vivo, and also showed good physicochemical properties by introduced trifluoromethyl group at the C-6 position.