221165-76-0

Upstream product

• 3173-56-6 benzyl isothiocyanate 
• 221164-26-7 ethyl 3,4-dihydro-7-[4-(hydroxymethyl)imidazol-1-yl]-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate 
• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 
• 2145-38-2 4-fluoro-3-(trifluoromethyl)acetanilide 
• 791823-71-7 N-[4-(4-hydroxymethyl-imidazol-1-yl)-2-nitro-5-trifluoromethyl-phenyl]-N-(4-methoxy-benzyl)-acetamide 
• 221167-32-4 4-[4-(hydroxymethyl)imidazol-1-yl]-2-nitro-5-(trifluoromethyl)aniline 
• 221167-34-6 4-[4-(hydroxymethyl)imidazol-1-yl]-5-(trifluoromethyl)-1,2-phenylenediamine 
• 143151-01-3 4-fluoro-2-nitro-5-(trifluoromethyl)acetanilide 
• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 

Relevant academic research and scientific papers

Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group

We describe the synthesis, physicochemical and biological properties of a novel series of 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acids with a substituted phenyl group. Among them, compound 9k (KRP-199) was found to possess high potency and selectivity for the AMPA-R and to exhibit good neuroprotective effects in vivo, and also showed good physicochemical properties by introduced trifluoromethyl group at the C-6 position.

6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives, addition salts thereof, and processes for the preparation of both

The present invention provides 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid compounds and their addition salts, and processes for preparing them, which have antagonism against excitatory amino acid receptors, in particular, an AMPA receptor