22117-57-3

Basic information

• Product Name: 3,4-Dihydro-6-methoxy-2-phenylnaphthalene
• Synonyms: 3,4-Dihydro-6-methoxy-2-phenylnaphthalene
• CAS NO: 22117-57-3
• Molecular Weight: 236.313
• Mol File: 22117-57-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3,4-Dihydro-6-methoxy-2-phenylnaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dihydro-6-methoxy-2-phenylnaphthalene(22117-57-3)
• EPA Substance Registry System: 3,4-Dihydro-6-methoxy-2-phenylnaphthalene(22117-57-3)

Safety Data

• Hazardous Substances Data: 22117-57-3(Hazardous Substances Data)

Upstream product

• 2472-22-2 6-methoxy-2-tetralone 
• 52178-91-3 7-methoxy-1,2-dihydronaphthalene 
• 1730-48-9 6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 55088-84-1 4-methoxybenzylidenecyclopropane 
• 98-09-9 benzenesulfonyl chloride 
• 68294-03-1 2-(carboxymethyl)-4-methoxybenzoic acid 
• 74317-85-4 2-bromo-4-methoxybenzoic acid 
• 591-51-5 phenyllithium 
• 135-76-2 sodium 2-naphthol-6-sulfonate 
• 65472-33-5 3,7-dimethoxy-1,2-dihydro-naphthalene 
• 5486-55-5 2,6-dimethoxylnaphthalene 
• 581-43-1 2.6-dihydroxynaphthalene 
• 128333-16-4 1,2-Dihydro-4-methoxybenzocyclobuten-1-yl phenyl ketone 

Downstream Products

• 94823-84-4 1.2.3.4.5.8-Hexahydro-6-methoxy-2-phenyl-naphthalin 

Relevant articles and documents

COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices.

Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3–sp2 and sp2–sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds

A valuable umpolung strategy that highlights the ambiphilic nature of the bis(phenylsulfonyl)methyl synthon and demonstrates its utility as a synthetic linchpin is reported. Although the bis(phenylsulfonyl)methyl group is typically introduced as an sp3-carbon nucleophile, it is demonstrated that it can also function as an effective sp2-carbon electrophile in the presence of organolithium nucleophiles. Alkyl- and aryllithiums couple with the central carbon of the bis(phenylsulfonyl)methyl unit to ultimately generate trisubstituted alkenes, comprising formal sp3–sp2 and sp2–sp2 cross-couplings between organolithium reagents and bis(sulfones). This process occurs almost instantaneously at ?78 °C in the absence of any transition metals. By developing this curious transformation, it has been demonstrated that bis(phenylsulfonyl)methane is a valuable synthetic linchpin, which can undergo two C?C bond-forming processes as an sp3-nucleophile, followed by a third C?C bond-forming reaction as an effective sp2-electrophile. This discovery significantly enhances the utility of this ubiquitous, but underutilized, linker group.

Inhibitors of acyl CoA:cholesterol acyltransferase

Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4- Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 μM in an in vitro rat hepatic microsomal ACAT assay, ED50 = 0.72 mg/kg/day in cholesterol-fed hamsters).