22117-57-3

Upstream product

• 128333-23-3 1,2-Dihydro-4-methoxy-1-(1-phenylvinyl)benzocyclobutene 
• 2472-22-2 6-methoxy-2-tetralone 
• 50886-32-3 6-methoxy-3,4-dihydro-naphthalen-1-yl acetate 
• 60100-19-8 4-methoxybenzocyclobutene-1-carboxylic acid 
• 5486-55-5 2,6-dimethoxylnaphthalene 
• 65472-33-5 3,7-dimethoxy-1,2-dihydro-naphthalene 
• 52178-91-3 7-methoxy-1,2-dihydronaphthalene 
• 1730-48-9 6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 74317-85-4 2-bromo-4-methoxybenzoic acid 
• 55088-84-1 4-methoxybenzylidenecyclopropane 
• 98-09-9 benzenesulfonyl chloride 
• 68294-03-1 2-(carboxymethyl)-4-methoxybenzoic acid 
• 591-51-5 phenyllithium 

Downstream Products

• 94823-84-4 1.2.3.4.5.8-Hexahydro-6-methoxy-2-phenyl-naphthalin 

Relevant academic research and scientific papers

COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices.

Preparation method of 7-methoxy-3-phenyl-1,2-dihydronaphthalene

The invention discloses a preparation method of 7-methoxy-3-phenyl-1,2-dihydronaphthalene. 4-methoxyphenylmethylene cyclopropane and benzenesulfonyl chloride are used as raw materials to directly prepare the 7-methoxy-3-phenyl-1,2-dihydronaphthalene. Acco

Sulfones as Synthetic Linchpins: Transition-Metal-Free sp3–sp2 and sp2–sp2 Cross-Couplings Between Geminal Bis(sulfones) and Organolithium Compounds

A valuable umpolung strategy that highlights the ambiphilic nature of the bis(phenylsulfonyl)methyl synthon and demonstrates its utility as a synthetic linchpin is reported. Although the bis(phenylsulfonyl)methyl group is typically introduced as an sp3-carbon nucleophile, it is demonstrated that it can also function as an effective sp2-carbon electrophile in the presence of organolithium nucleophiles. Alkyl- and aryllithiums couple with the central carbon of the bis(phenylsulfonyl)methyl unit to ultimately generate trisubstituted alkenes, comprising formal sp3–sp2 and sp2–sp2 cross-couplings between organolithium reagents and bis(sulfones). This process occurs almost instantaneously at ?78 °C in the absence of any transition metals. By developing this curious transformation, it has been demonstrated that bis(phenylsulfonyl)methane is a valuable synthetic linchpin, which can undergo two C?C bond-forming processes as an sp3-nucleophile, followed by a third C?C bond-forming reaction as an effective sp2-electrophile. This discovery significantly enhances the utility of this ubiquitous, but underutilized, linker group.

Copper-catalyzed alkene arylation with diaryliodonium salts

Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad applications in chemical synthesis.

Inhibitors of acyl CoA:cholesterol acyltransferase

Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4- Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 μM in an in vitro rat hepatic microsomal ACAT assay, ED50 = 0.72 mg/kg/day in cholesterol-fed hamsters).

Synthesis of 2,6-Disubstituted Dihydronaphthalenes and Naphthalenes by Electrocyclic Reaction of o-Quinodimethane. A Synthesis of (+/-)-Naproxen

A survey of the electrocyclic reactions of o-quinodimethanes generated in situ by the thermolysis of dihydrobenzocyclobutenes with a variety of olefinic substituents at C-1 is reported.These reactions provide convenient access to the 2,6-disubstituted dihydronaphthalenes (11) and the naphthalenes (12).Thermolysis of the benzocyclobutenes (10) at 180 deg C in the presence of manganese dioxide affords in good yields the 2,6-di- and 2,3,6-tri-substituted naphthalenes (12) and (16).The naphthalenes (12b,f,h) thus obtained were easily converted into (+/-)-naproxen (5).