22117-90-4

Upstream product

• 109-72-8 n-butyllithium 
• 1871-76-7 diphenylacetic acid chloride 
• 22932-01-0 Benzoic acid 1-(hydroxy-diphenyl-methyl)-pentyl ester 
• 930-68-7 cyclohexenone 
• 86-29-3 Diphenylacetonitrile 
• 947-91-1 Diphenylacetaldehyde 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 22932-08-7 1,1-Diphenyl-1,2-hexandiol 
• 781-35-1 1,1-diphenylacetone 
• 80376-94-9 N-Butyl-N'-tert-butyl-N-(2,2-diphenyl-vinyl)-formamidine 
• 41997-49-3 1,1-diphenyl-2-hexanol 
• 80376-99-4 N-(1-Benzhydrylidene-pentyl)-N-butyl-N'-tert-butyl-formamidine 
• 540-54-5 1-Chloropropane 
• 86543-51-3 1,1-Diphenyl-2-propanone Dianion 

Downstream Products

• 51262-94-3 S-(-)-1,1-Diphenyl-hexan-2-ol 
• 52199-77-6 Phthalic acid mono-(1-benzhydryl-pentyl) ester 
• 52248-09-6 Phthalic acid mono-((S)-1-benzhydryl-pentyl) ester 
• 41997-49-3 1,1-diphenyl-2-hexanol 

Relevant academic research and scientific papers

Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators

A series of compounds with a diphenylmethyl cyclohexyl skeleton, loosely related to verapamil, has been synthesized and tested as MDR modulators on anthracycline-resistant erythroleukemia K 562 cells. Their residual cardiovascular action (negative inotrop

Cerium(III) chloride remarkably increases the rates of formation and yields of ketones in the reaction of lithium carboxylates with organolithiums

The presence of CeCl3 greatly increases the yield of ketones in the reaction of organolithiums with lithium carboxylates. The CE(III) suppresses the enolization of the lithium carboxylate, previously unrecognized as a competing reaction except in special cases, and the formation of tertiary alcohols. One of the reasons for the latter effect is a surprising increase in the rate of addition of the organometallic to the lithium carboxylate in the presence of Ce(III).

α-Amino Carbanions. Preparation, Metalation, and Alkylation of Enamidines. Synthesis of Piperidine and Pyrrolidine Natural Products and Homologation of Carbonyl Compounds

Saturated heterocycles, as their tert-butylformamidines, may be transformed into enamidines, by metalation-selenation-elimination.These enamidines are valuable precursors to 2-substituted, 2,4-disubstituted, and 2,4,6-trisubstituted pyrrolidines, piperidines, and perhydroazepines, prepared in a regiospecific manner.The method is demonstrated by the synthsesis of selenopsin A and the red fire ant venom.The use of acyclic enamidines is displayed as a homologation reagent which converts carbonyl compounds to higher alkyl derivatives.

Formation and Reactions of 1-Phenyl-2-propanone Dianion and Related Systems with Electrophilic Reagents

1-Phenyl-2-propanone, 1,1-diphenyl-2-propanone, and 1-(4-methoxyphenyl)-2-propanone were converted to their dicarbanions 3, 4, and 31, respectively, and their reactions with a number of electrophilic reagents were examined.All three dianions gave a mixture of C-1 and C-3 alkylation products when treated with alkyl halides of higher reactivity, while only C-1 alkylations occurred when alkyl halides of lower reactivity were used.It was also found that the 1,1-diphenyl-2-propanone and the 1-(4-methoxyphenyl)-2-propanone dianions 4 and 31 gave a higher ratio of C-1/C-3 alkylation products than the 1-phenyl-2-propanone dianion 3.When dianion 3 was reacted with p-anisaldehyde and a number of protonating agents, electrophilic attack occurred exclusively at the C-3 position.The trends observed are analyzed, and mechanisms are proposed to account for the results obtained.