221179-06-2

Upstream product

• 18523-22-3 2,3'-dibromoacetophenone 
• 221178-83-2 6-amino-1,2-dihydro-4-(4-hydroxyphenyl)-2-thioxopyridine-3,5-dicarbonitrile 
• 3785-90-8 2-(4-hydroxyphenylmethylene)malononitrile 
• 221178-81-0 2,6-diamino-4-(4-hydroxyphenyl)-4H-thiopyran-3,5-dicarbonitrile 

Relevant academic research and scientific papers

Synthesis and Recyclization of 4-Aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans

Reaction of arylmethylenemalononitriles with cyanothioacetamide or of arylmethylenecyanothioacetamides with malononitrile affords 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans which were further recyclized into 6-amino-4-aryl-3,5-dicyanopyridine-2(1H)-thiones. On the basis of the latter compounds were synthesized substituted 2-alkylthiopyridines and thieno[2,3-b]pyridines. 4-Hydroxybenzalcyanothioacetamide reacts with α-bromoketones by Hantzsch with the formation of thiazolylsubstituted acrylonitriles acylated with acetic anhydride at the OH group.