2212-04-6

Basic information

• Product Name: 2-[(2-chlorophenoxy)methyl]oxirane
• Synonyms: 1-(2-Chlorophenoxy)-2,3-epoxypropane; 1,2-Epoxy-3-chlorophenoxypropane; Chlorophenyl glycidyl ether; oxirane, 2-[(2-chlorophenoxy)methyl]-
• CAS NO: 2212-04-6
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.6196
• Mol File: 2212-04-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 270.8°C at 760 mmHg
• Flash Point: 114.9°C
• Density: 1.267g/cm³
• Vapor Pressure: 0.0111mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 2-[(2-chlorophenoxy)methyl]oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-chlorophenoxy)methyl]oxirane(2212-04-6)
• EPA Substance Registry System: 2-[(2-chlorophenoxy)methyl]oxirane(2212-04-6)

Safety Data

• Hazardous Substances Data: 2212-04-6(Hazardous Substances Data)

Usage

Physical properties

colorless, flammable, volatile liquid

Uses

production of plastics, glycerol, epoxy resins; solvent and stabilizer in organic chemical production

Hazards

toxic to humans, causes skin, respiratory, and eye irritation; known carcinogen; environmental harm if released

Safety measures

proper handling required

Upstream product

• 95-57-8 2-monochlorophenol 
• 152333-94-3 glycidyl nosylate 
• 2954-50-9 2-aminotetralin 
• 106-89-8 epichlorohydrin 

Downstream Products

• 108239-32-3 1-(2-chloro-phenoxy)-3-piperidino-propan-2-ol 
• 1716-44-5 3-(2-Chlor-phenoxy)-2-hydroxy-propylfluorid 
• 50714-54-0 1-amino-3-(2-chloro-phenoxy)-propan-2-ol 
• 21269-20-5 1-(2-chloro-phenoxy)-3-[methyl-(2-morpholin-4-yl-ethyl)-amino]-propan-2-ol 
• 110146-48-0 1-(2-chloro-phenoxy)-3-[4-(3-chloro-phenyl)-piperazino]-propan-2-ol 
• 99177-69-2 1-(2-chloro-phenoxy)-3-methylamino-propan-2-ol 
• 100141-67-1 1-allylamino-3-(2-chloro-phenoxy)-propan-2-ol 
• 52181-42-7 1-anilino-3-(2-chloro-phenoxy)-propan-2-ol 
• 39631-84-0 1-butylamino-3-(2-chloro-phenoxy)-propan-2-ol 
• 56057-14-8 1-(2-chloro-phenoxy)-3-diethylamino-propan-2-ol 
• 21925-70-2 3-<2-Chlor-phenoxy>-1-isopropylamino-propanol-(2) 
• 99980-92-4 1-(2-chloro-phenoxy)-3-dimethylamino-propan-2-ol 
• 109397-84-4 1-(2-chloro-phenoxy)-3-dibutylamino-propan-2-ol 
• 100880-07-7 1-(2-chloro-phenoxy)-3-pentylamino-propan-2-ol 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

A facile and efficient method for synthesis of β-iodocarboxylates from terminal epoxides

A facile and efficient method has been developed for synthesis of β-iodocarboxylates in the presences of Ph3P/I2. Starting from epoxides, a series of β-iodocarboxylate compounds can be directly obtained in toluene media with excellent yields. Moreover, the method was successfully applied for the late-stage modification of natural products, such as isosteviol and vincamine derivatives, achieving the corresponding β-iodocarboxylates in good yields.

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors

We previously reported 4-(3-((6-bromonaphthalen-2-yl)oxy)-2-hydroxypropyl)-N,N-dimethylpiperazine-1-sulfonamide (1) as a novel heat shock protein 90 inhibitor with moderate activity. In our ongoing efforts for the discovery of Hsp90 modulators we undertake structural investigations on 1. Series of the titled compound were designed, synthesized and evaluated. We have found that compounds with a hydroxyl group at C-4 of the aryl ring on the piperazine moiety possess Hsp90 inhibition properties. Compound 6f with improved activity could be further developed and optimized as Hsp90 inhibitor.