22120-32-7

Usage

Uses

Given the nature of the provided materials, there are no specific applications listed for 5-CHLORO-N,N-DIMETHYLTRYPTAMINE in terms of industrial or medicinal uses. The primary focus of the material is on its psychoactive and hallucinogenic properties, which are not typically associated with standard applications in various industries. However, it is important to note that research into psychoactive substances can sometimes lead to a better understanding of the brain and mental health, potentially contributing to the development of new therapeutic approaches. Yet, such uses would be speculative and not based on the provided materials.
If in the future there are identified applications, they would be described as follows:
Used in [Application Industry]:
5-CHLORO-N,N-DIMETHYLTRYPTAMINE is used as [application type] for [application reason]
For example, if it were used in a specific industry for a certain purpose, the description would be adjusted accordingly to reflect that use. However, as of the current information provided, no such applications are listed.

InChI:InChI=1/C12H15ClN2/c1-15(2)6-5-9-8-14-12-4-3-10(13)7-11(9)12/h3-4,7-8,14H,5-6H2,1-2H3

Upstream product

• 19718-92-4 4-(N,N-dimethylamino)butyraldehyde dimethyl acetal 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 161202-91-1 1-hydroxy-N,N-dimethyltryptamine 
• 3764-94-1 5-chlorotryptamine 
• 74-88-4 methyl iodide 
• 120-72-9 indole 
• 61-50-7 N,N-dimethyltryptamine 
• 29095-44-1 2-(1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide 
• 38662-17-8 2-(dihydroindol-3-yl)-N,N-dimethylethylamine 
• 50-00-0 formaldehyd 
• 942-26-7 5-chlorotryptamine hydrochloride 

Downstream Products

• 639808-95-0 2-[1-(2-bromobenzyl)-5-chloroindol-3-yl]ethyl-N,N-dimethylamine 
• 154323-57-6 almotriptan 

Relevant academic research and scientific papers

Indole derivatives and its application on the medicament

The invention provides indole derivatives or stereisomers, tautomers, nitrogen oxides, solvate, metabolic products, pharmaceutically acceptable salts or prodrugs thereof for treating the alzheimer disease. The invention further discloses a pharmaceutical composition containing the compounds and a method of using the compounds or the pharmaceutical composition thereof to treat the alzheimer disease.

Synthesis and structureactivity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands

5-Hydroxytryptamine 6 receptors (5-HT6R) are being perceived as the possible target for treatment of cognitive disorders as well as obesity. The present article deals with the design, synthesis, in vitro binding and structureactivity relationship of a novel series of tetracyclic tryptamines with the rigidized N-arylsulphonyl, N-arylcarbonyl and N-benzyl substituents as 5-HT6 receptor ligands. The chiral sulphonyl derivatives 15a and 17a showed high affinity at 5-HT6R with the Ki of 23.4 and 20.5nM, respectively. The lead compound from the series 15a has acceptable ADME properties, adequate brain penetration and is active in animal models of cognition like Novel Object Recognition Task (NORT) and water maze.

Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus

A series of tryptamine derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent antiviral activity (IC50 = 0.4 and 50 = 40.6 and >25 μM, respectively).

A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and β-carbolines

(matrix presented) Various tryptamines are captured by a vinylsulfonylmethyl polystyrene resin, generating a safety-catch linkage. β-Carbolines can be formed from 4 by a Pictet-Spengler reaction with the introduction of R1. Tryptamine 4 can also be derivatized by acylation or copper-mediated coupling to introduce R2. If X = Br, Suzuki coupling can be used to introduce R3. After derivatization, the indole derivatives are activated with methyl iodide and released under mild basic condition.

SIMPLE SYNTHESES OF LESPEDAMINE AND 5-BROMO-N,N-DIMETHYLTRYPTAMINE BASED ON 1-HYDROXYINDOLE CHEMISTRY

Various types of 1-hydroxyindoles were prepared for the first time.Through methylation or acid catalyzed nucleophilic bromination of N,N-dimethyl-1-hydroxytryptamine, simple syntheses of lespedamine and 5-bromo-N,N-dimethyltryptamine were achieved, respectively.