22121-60-4

Upstream product

• 1226-33-1 ethyl 2-((5,6-dimethylcyclohexa-2,4-dien-1-yl)amino)benzoate 
• 61-68-7 mefenamic Acid 
• 1222-42-0 methyl 2-[(2,3-dimethylphenyl)amino]benzoate 

Downstream Products

• 1262051-05-7 C₂₂H₂₀N₄O₃ 
• 905094-56-6 C₂₂H₂₁N₃O₂ 
• 1313023-83-4 N-(2-chloro-3-[(2-(2-(2,3-dimethylphenylamino)benzoyl)hydrazono)methyl]-7-phenoxyquinolin-6-yl)methanesulfonamide 
• 1334814-48-0 (Z)-N'-(1-benzyl-2-oxoindolin-3-ylidene)-2-(2,3-dimethylphenylamino)benzohydrazide 

Relevant academic research and scientific papers

Synthesis, analgesic and anti-inflammatory activities of chalconyl-incorporated hydrazone derivatives of mefenamic acid

A series of chalconyl-incorporated hydrazone derivatives of mefenamic acid was synthesized in order to obtain new compounds with potential analgesic and anti-inflammatory activity having lesser side effects. The structures of all synthesized compounds were confirmed by means of elemental analysis, IR, 1H NMR, 13C NMR and mass spectra. All compounds were evaluated for their analgesic and anti-inflammatory activities by tail-flick method and carrageenan-induced rat paw edema test, respectively. Among all the synthesized compounds, compounds (4a) and (4j) exhibited the most prominent and consistent anti-inflammatory activity. In acute ulcerogenicity study, it can be concluded that compounds (4a) and (4j) are devoid of the deadlier gastrointestinal toxicities.

Synthesis and characterization of some new five and seven-membered heterocyclic compounds derived from mefenamic acid

Five and seven-membered heterocyclic compounds were prepared from mefenamic acid, which was esterified with absolute ethanol to give amino benzoate (Z1). The ester reaction with hydrazine hydrate gave benzohydrazide (Z2), then converted into Schiff base b

Identification and investigation of the chelating activity of some phenolic polymers derived from mefenamic acid

NEW phenol formaldehyde resin synthesized from multi steps, the first step converts mefenamic acid to their ester ethyl 2-((2,3-dimethylphenyl) amino) benzoate (T1) by reaction with ethanol catalyzed by sulfuric acid as a catalyzed. The hydrazide derivati

Synthesis, crystal structure, Hirshfeld surface analysis and DFT calculations of 2-[(2,3-dimethylphenyl)amino]-N’-[(E)-thiophen-2-ylmethylidene]benzohydrazide

Hydrazones are an important class of organic compounds, which exhibit large pharmacological applications. Hydrazones have long been used for the synthesis of a wide range of useful heterocyclic compounds due to their reactivity toward electrophiles and nu

Synthesis, experimental and theoretical characterization of (E)-2-((2,3-dimethylphenyl)amino)-N’-(furan-2-ylmethylene)benzohydrazide

Hydrazone derivatives have drawn much attention because of their large pharmacological applications. In the present work, the compound (E)-2-((2,3-dimethylphenyl)amino)-N’-(furan-2-ylmethylene)benzohydrazide, noted C20H19N3/sub

Synthesis and evaluation of some new hydrazones as corrosion inhibitors for mild steel in acidic media

Mild steel corrosion in HCl solution is an example of corrosion in acidic mediums. The ongoing research efforts to develop novel environmentally friendly corrosion inhibitors raise questions regarding their ability to effectively protect steel from corros

Microwave-assisted one-step synthesis of fenamic acid hydrazides from the corresponding acids

A facile and efficient method for synthesis of fenamic acid hydrazides from their acids in one-step reaction under microwave irradiation and solvent-free conditions was developed. Compared with the two-step conventional heating method, the process was simple, the reaction time was very short and the yields were almost quantitative.

Design and synthesis of 1-aroyl-2-ylidene hydrazines under conventional and microwave irradiation conditions and their cytotoxic activities

We report the design and synthesis of 1-aroyl-2-(alkenyl/aryl)idene hydrazines as hybrid molecules derived from mefenamic acid and substituted hydrazones. A number of compounds based on this new scaffold were prepared in good yields. The key intermediate