22121-60-4Relevant articles and documents
Synthesis, analgesic and anti-inflammatory activities of chalconyl-incorporated hydrazone derivatives of mefenamic acid
Kumar, Neeraj,Chauhan, Lalit Singh,Sharma, Chandra Shekhar,Dashora, Nipun,Bera, Rajendra
, p. 2580 - 2590 (2015)
A series of chalconyl-incorporated hydrazone derivatives of mefenamic acid was synthesized in order to obtain new compounds with potential analgesic and anti-inflammatory activity having lesser side effects. The structures of all synthesized compounds were confirmed by means of elemental analysis, IR, 1H NMR, 13C NMR and mass spectra. All compounds were evaluated for their analgesic and anti-inflammatory activities by tail-flick method and carrageenan-induced rat paw edema test, respectively. Among all the synthesized compounds, compounds (4a) and (4j) exhibited the most prominent and consistent anti-inflammatory activity. In acute ulcerogenicity study, it can be concluded that compounds (4a) and (4j) are devoid of the deadlier gastrointestinal toxicities.
Identification and investigation of the chelating activity of some phenolic polymers derived from mefenamic acid
Al-Mathkuri, Tahseen Saddam Fandi,Al-Hilfi, Jassim Abas,Al-Jubori, Hamid Mohammed Saleh
, p. 155 - 169 (2020/04/09)
NEW phenol formaldehyde resin synthesized from multi steps, the first step converts mefenamic acid to their ester ethyl 2-((2,3-dimethylphenyl) amino) benzoate (T1) by reaction with ethanol catalyzed by sulfuric acid as a catalyzed. The hydrazide derivati
Synthesis, experimental and theoretical characterization of (E)-2-((2,3-dimethylphenyl)amino)-N’-(furan-2-ylmethylene)benzohydrazide
Albayati, Mustafa R.,Ali, Ismat H.,Chung, Ill-Min,Dege, Necmi,Kans?z, Sevgi,Kaya, Sava?,Lgaz, Hassane,Salghi, Rachid
, (2020/06/18)
Hydrazone derivatives have drawn much attention because of their large pharmacological applications. In the present work, the compound (E)-2-((2,3-dimethylphenyl)amino)-N’-(furan-2-ylmethylene)benzohydrazide, noted C20H19N3/sub
