221221-03-0Relevant articles and documents
A practical synthesis of 3-chloro-2,4-difluoro-5-hydroxybenzoic acid
Zhang, Mingguang,Bi, Zhongbao,Wang, Yunyun,Zhao, Yuxun,Yang, Yang,Zhu, Yongqiang,Wang, Shifa
, p. 166 - 171 (2021)
A new and practical synthesis of 3-chloro-2,4-difluoro-5-hydroxybenzoic acid, a key intermediate for preparing antimicrobial 3-quinolinecarboxylic acid drugs, is synthesized from 2,4-difluoro-3-chlororobenzoic acid. The protocol involves nitration, esteri
An efficient synthesis of 2,4-difluoro-3,5-dichlorobenzoic acid
Zhou, Weiyou,Yu, Shuitao,Xia, Zhengjun,Zhang, Mingguang,Lin, Song,Chen, Zaixin
, p. 277 - 278 (2015/06/02)
2,4-Difluoro-3,5-dichlorobenzoic acid, as a key intermediate for preparing quinolone-3-carboxylic acids, was synthesised from the commercially available 2,4-difluoro-3-chlorobenzoic acid in excellent yield by a reaction sequence involving nitration, selec
6- (Heterocyclyl-substituted Benzyl) -4-Oxoquinoline Compound and Use Thereof as HIV Integrase Inhibitor
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Page/Page column 45, (2008/12/08)
The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical composition, an anti-HIV
ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES
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Page 79; 80, (2010/02/06)
Compounds of the following formula (I) are effective antimicrobial agents.
N3 alkylated benzimidazole derivatives as MEK inhibitors
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Page 61, (2008/06/13)
Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.
Antimicrobial quinolones, their compositions and uses
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, (2008/06/13)
Compounds having the general structure: which are effective antimicrobial agents.
Antimicrobial quinolones, their compositions and uses
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, (2008/06/13)
Compounds having the general structure: which are effective antimicrobial agents.
Process for making certain benzoic acid compounds
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Page column 12, (2010/01/30)
The subject invention involves processes for making 2,4-difluoro-3-Q1-benzoic acid, wherein Q1 is derived from an electrophilic reagent, comprising the steps of: (a) treating 1-bromo-2,4-difluorobenzene with a strong, non-nucleophilic base; then treating
Antimicrobial quinolones, their compositions and uses
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, (2008/06/13)
This invention relates to novel antimicrobial compounds of formula; wherein X, R1, R3, R5, R6, and R8 are defined in the claims, and to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically-acceptable salts, hydrates, and biohydrolyzable esters, amides and imides thereof, and to compositions and uses of such compounds. The invention also relates to compounds derived from these compounds having antimicrobial uses.