22123-53-1

Upstream product

• 630-19-3 pivalaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 10413-34-0 2-amino-3-cyano-4-tert-butyl-thiophene 

Relevant academic research and scientific papers

Synthesis of hybrid perillyl-4H-pyrans. Cytotoxicity evaluation against hepatocellular carcinoma HepG2/C3A cell line

A series of 15 new hybrid perillyl-4H-pyrans compounds was straightforwardly synthesized by a strategy combining the multicomponent reaction and the copper-catalyzed alkyne-azide cycloaddition (CuAAC). The 2-amino-4H-pyrans-3-carbonitrile containing the a

Green synthesis of a nano salt and its application as multifunctional organocatalyst for Knoevenagel condensation

1,2-Ethanediammonium 3-hydroxypropane-1-sulfonate [(EDA)(HPS)] as a novel nano multifunctional organosalt was synthesized via a simple and green chemical route and characterized using various techniques such as proton nuclear magnetic resonance (1/s

Utilization of hexagonal boron nitride as a solid acid–base bifunctional catalyst

This work explores the use of hexagonal boron nitride (h-BN), a graphite-like compound, as a novel catalyst with base and acid functionalities. For use as a solid catalyst, the layered structure of h-BN was disrupted by ball-milling, exposing boron and ni

Fluorous bispidine: A bifunctional reagent for copper-catalyzed oxidation and knoevenagel condensation reactions in water

Fluorous bispidine-type ligands have been developed to facilitate its recovery and reusability and to demonstrate its bifunctional property as a ligand and base in copper-catalyzed aerobic oxidation, the Knoevenagel condensation and tandem oxidation/Knoevenagel condensation in water under mild conditions. Application of the fluorous ligand was also extended to the surfactant-free copper-catalyzed allylic and benzylic sp3 C-H oxidation reaction in water. The fluorous ligands could be recovered using F-SPE with recovery ranging from 91-97% and could be reused five times with little loss of activity.

Hierarchical high-silica zeolites as superior base catalysts

For more than four decades, the design of zeolite base catalysts has relied on the application of aluminium-rich frameworks exchanged with alkali metal cations (preferably Cs+). However, moderate activity associated with access and diffusion limitations, and high manufacturing costs associated with high caesium content (typically over 30%) have hampered their industrial implementation so far. Herein, we have discovered that high-silica USY zeolites outperform their Al-rich counterparts in a variety of base-catalysed reactions of relevance in the fine chemical industry, as well as in the upgrading of biofuels. The benefits of this class of materials are amplified upon the alleviation of diffusion constraints through the introduction of a network of intracrystalline mesopores by post-synthetic modification. For example, the resulting cation-free hierarchical USY provides an up to 30-fold Knoevenagel condensation activity compared to the benchmark Cs-X, and similar observations were made upon application in liquid-phase (nitro)aldol reactions. Moreover, in the gas-phase aldol condensation of propanal, high-silica zeolites provide superior activity, selectivity, and lifetime compared to caesium-containing zeolites and even a strong solid base such as MgO. We decouple the complex interplay between mesoporosity and intrinsic zeolitic properties such as crystallinity, and quantify the increase in catalyst effectiveness upon hierarchical structuring as a function of reactant size. The obtained results are a major step to resolve the drawbacks of zeolites catalysis and thereby revitalise their potential for industrial application.

Isocyanide-based multicomponent reactions: Catalyst-free stereoselective construction of polycyclic spiroindolines

A novel catalyst-free one-pot tandem reaction for the stereoselective construction of polycyclic spiroindolines was developed. This method offers a straightforward access to structurally diverse polycyclic spiroindoline derivatives in high yields (up to 90%) with excellent levels of diastereoselectivity.

Potassium Channel Modulators

Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein R1, R2, R3, R4, and R5 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

Chloride ion pairs as catalysts for the alkylation of aldehydes and ketones with C-H acidic compounds

Chloride anions associated with various soft cations (like tetraalkyl ammoniums, alkyl imidazoliums or pyridiniums) were shown to be able to promote the alkylation of carbonyl derivatives with acidic compounds, as exemplified on Knoevenagel and aldol condensations under relatively mild conditions. This activity was attributed to an enhanced nucleophilicity of the chlorine anion, originating from a softness/hardness mismatch between the anion and the cation.

Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)4-catalyzed Kn?evenagel reactions

Kn?evenagel reactions of aldehydes and ketones with malononitrile, isopropyl cyanoacetate and diisopropyl malonate catalyzed by Ti(O-i-Pr) 4 proceeded smoothly in i-PrOH to give the corresponding reaction products in good to high yield. 3-Substituted coumarins were prepared by the present method.

Catalytic and highly regiospecific carbon-carbon bond formation at α-position of Michael acceptor by palladium complex

Activated olefins react with allyl acetates and Bu3SnH in the presence of a catalytic amount of a palladium catalyst to afford the corresponding products which construct a new C-C bond selectively at the α-position of Michael acceptors.