221278-35-9

Upstream product

• 89872-96-8 1,5-anhydro-4,6-O-benzylidene-2-O-tert-butyldimethylsilyl-D-glucitol 
• 3282-30-2 pivaloyl chloride 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 221278-34-8 1,5-anhydro-3-O-pivaloyl-D-glucitol 

Downstream Products

• 221278-36-0 1,5-anhydro-6-O-monomethoxytrityl-3-O-pivaloyl-4-deoxy-D-glucitol 

Relevant academic research and scientific papers

Synthesis and conformational analysis of 1,5-anhydro-2,4 dideoxy-D- mannitol nucleosides

1,5-Anhydro-4,6-O-benzylidene-D-glucitol was used as starting material for the synthesis of 1,5-anhydro-2,4-dideoxy-D-mannitol nucleosides with an adenine and uracil base moiety. The compound with a purine base was obtained by direct nucleophilic substitution of a triflate. The pyrimidine nucleoside could be obtained by epoxide opening followed by inversion of configuration at the 3'-position. Both nucleosides adopt a C1 conformation with an axial base moiety.