221278-44-0Relevant articles and documents
Synthesis and conformational analysis of 1,5-anhydro-2,4 dideoxy-D- mannitol nucleosides
Hossain,Luyten,Rothenbacher,Busson,Herdewijn
, p. 161 - 180 (2007/10/03)
1,5-Anhydro-4,6-O-benzylidene-D-glucitol was used as starting material for the synthesis of 1,5-anhydro-2,4-dideoxy-D-mannitol nucleosides with an adenine and uracil base moiety. The compound with a purine base was obtained by direct nucleophilic substitution of a triflate. The pyrimidine nucleoside could be obtained by epoxide opening followed by inversion of configuration at the 3'-position. Both nucleosides adopt a C1 conformation with an axial base moiety.