221285-25-2

Usage

Uses

Used in Pharmaceutical Industry:
Benzenemethanol, 2-amino-6-fluoro(9CI) is used as a key intermediate in the synthesis of pharmaceuticals. Its unique chemical structure allows for the development of new compounds with potential therapeutic applications. The fluoro and amino groups in its structure can be utilized to create novel drug candidates with improved pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical industry, Benzenemethanol, 2-amino-6-fluoro(9CI) serves as an important building block for the synthesis of various agrochemicals. Its unique reactivity and functional groups enable the development of new compounds with enhanced pesticidal or herbicidal properties, contributing to more effective and sustainable agricultural practices.
Used in Organic Chemistry:
Benzenemethanol, 2-amino-6-fluoro(9CI) is also used in organic chemistry as a versatile intermediate for the synthesis of a wide range of organic compounds. Its fluoro and amino groups provide unique reactivity, allowing for the formation of various functional groups and the creation of novel organic molecules with potential applications in various fields.
It is important to handle and use Benzenemethanol, 2-amino-6-fluoro(9CI) with caution due to its potential hazards and toxicity. Proper safety measures should be taken during its synthesis, storage, and application to minimize any risks associated with its use.

InChI:InChI=1/C7H8FNO/c8-6-2-1-3-7(9)5(6)4-10/h1-3,10H,4,9H2

Upstream product

• 434-76-4 2-amino-6-fluorobenzoic acid 
• 86505-94-4 2-amino-6-fluoro-benzoic acid,methyl ester 

Downstream Products

• 426216-27-5 5-fluoro-2-phenyl-1,4-dihydro-2H-benzo[d][1,3]oxazine 
• 151585-93-2 2-amino-6-fluorobenzaldehyde 
• 885610-00-4 N-(3-fluoro-2-(hydroxymethyl)phenyl)pivalamide 
• 1347720-76-6 C₂₁H₂₄FN₃O₅ 
• 1620102-81-9 tert-butyl (2-(chloromethyl)-3-fluorophenyl)carbamate 
• 1222094-48-5 5-fluoro-2-phenylquinazoline 
• 1222094-47-4 5-fluoro-2-(4-methoxyphenyl)quinazoline 
• 1222094-46-3 2-(4-chlorophenyl)-5-fluoroquinazoline 
• 1086392-03-1 tert-butyl (3-fluoro-2-formylphenyl)carbamate 

Relevant academic research and scientific papers

Heavy-Atom Tunneling Through Crossing Potential Energy Surfaces: Cyclization of a Triplet 2-Formylarylnitrene to a Singlet 2,1-Benzisoxazole

Not long ago, the occurrence of quantum mechanical tunneling (QMT) chemistry involving atoms heavier than hydrogen was considered unreasonable. Contributing to the shift of this paradigm, we present here the discovery of a new and distinct heavy-atom QMT

A [4 + 3] Annulation Reaction of aza- o-Quinone Methides with Arylcarbohydrazonoyl Chlorides for Synthesis of 2,3-Dihydro-1 H-benzo[ e][1,2,4]triazepines

An unprecedented [4 + 3] annulation reaction of aza-ortho-quinone methides with arylcarbohydrazonoyl chlorides has been achieved under mild conditions. The annulation underwent a sequential conjugate addition/intramolecular annulation/rearrangement, providing a useful method for the synthesis of biologically interesting 2,3-dihydro-1H-benzo[e][1,2,4]triazepine.

Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives

A Pd-catalyzed, highly regioselective and stereoselective three-component domino allylic substitution/N-H carbene insertion reaction under mild conditions is described. This reaction demonstrates a wide substrate scope and satisfactory functional group tolerance, providing a broad range of allylic sulfone-containing amino acid derivatives. Moreover, DBU mediates highly diastereoselective cross-dehydrogenative coupling annulation of allylic sulfones without using peroxides or any metal oxidants. This developed protocol affords 7-membered ring heterocyclic compounds incorporating both sulfone-containing amino acid esters and one quaternary carbon center. Mechanistic studies indicate that an unusual umpolung of glycine occurred in this annulation.

Catalytic Asymmetric Construction of the Tryptanthrin Skeleton via an Enantioselective Decarboxylative [4 + 2] Cyclization

The first catalytic asymmetric construction of the tryptanthrin skeleton has been established, taking advantage of a palladium(0)/chiral ligand-catalyzed enantioselective decarboxylative [4 + 2] cyclization of vinyl benzoxazinanones with isatins. This rea

Iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines: Synthesis of quinazolines by trapping of ammonia

A novel approach to construct 2-aryl/heteroaryl quinazolines was developed through an iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines under aerobic oxidative conditions. The reaction proceeds via the formation of N-benzylideneb

Tandem [3 + 2] cycloaddition/1,4-addition reaction of azomethine ylides and aza-o-quinone methides for asymmetric synthesis of imidazolines

An enantioselective synthesis of biologically important imidazolidines has been achieved via a tandem [3 + 2] cycloaddition/1,4-addition reaction of azomethine ylide and aza-o-quinone methides. With the use of this tool, various imidazolidine derivatives are obtained in good yields with excellent diastereoselectivities and enantioselectivities.

N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles

A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported. Umpolung: N-heterocyclic carbene catalysis is used for the convergent and efficient transition-metal-free synthesis of 2-aryl-indoles. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent is central to this successful strategy. The reaction exhibits high yields and a wide scope, and it has been applied to a streamlined synthesis of a kinase inhibitor.

HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorde

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.

HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF

This invention relates to known and novel hydroxyquinolin-2(1H)-ones and derivatives thereof which are useful for the treatment of cognitive-related disorders and neuropathic pain disorders in a mammal, e.g., a human. The invention also relates to pharmaceutical compositions containing such compounds.