221285-25-2

Basic information

• Product Name: Benzenemethanol, 2-amino-6-fluoro- (9CI)
• Synonyms: Benzenemethanol, 2-amino-6-fluoro- (9CI);BenzeneMethanol, 2-aMino-6-fluoro-;(2-AMino-6-fluorophenyl)Methanol;(2-Amino-6-fluorophenyl)
• CAS NO: 221285-25-2
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.1429232
• Product Categories: VARIOUSAMINE
• Mol File: 221285-25-2.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 287.265°C at 760 mmHg
• Flash Point: 127.534°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Benzenemethanol, 2-amino-6-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-amino-6-fluoro- (9CI)(221285-25-2)
• EPA Substance Registry System: Benzenemethanol, 2-amino-6-fluoro- (9CI)(221285-25-2)

Safety Data

• Hazardous Substances Data: 221285-25-2(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 2-amino-6-fluoro- (9CI) is a chemical compound that belongs to the aromatic alcohols and derivatives class. It is identified by its chemical structure, which consists of a benzene ring attached to a methanol group and an amino group at the 2nd position with a fluorine atom at the 6th position. Benzenemethanol, 2-amino-6-fluoro- (9CI) is primarily used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its properties make it a valuable intermediate in chemical reactions, and its fluoro and amino groups can provide unique reactivity in the development of new compounds. Additionally, it is important to handle and use this compound with caution due to its potential hazards and toxicity.

InChI:InChI=1/C7H8FNO/c8-6-2-1-3-7(9)5(6)4-10/h1-3,10H,4,9H2

Upstream product

• 86505-94-4 2-amino-6-fluoro-benzoic acid,methyl ester 
• 434-76-4 2-amino-6-fluorobenzoic acid 

Downstream Products

• 426216-27-5 5-fluoro-2-phenyl-1,4-dihydro-2H-benzo[d][1,3]oxazine 
• 151585-93-2 2-amino-6-fluorobenzaldehyde 
• 1086392-03-1 tert-butyl (3-fluoro-2-formylphenyl)carbamate 
• 1222094-46-3 2-(4-chlorophenyl)-5-fluoroquinazoline 
• 1222094-47-4 5-fluoro-2-(4-methoxyphenyl)quinazoline 
• 1222094-48-5 5-fluoro-2-phenylquinazoline 
• 1620102-81-9 tert-butyl (2-(chloromethyl)-3-fluorophenyl)carbamate 

Relevant articles and documents

Heavy-Atom Tunneling Through Crossing Potential Energy Surfaces: Cyclization of a Triplet 2-Formylarylnitrene to a Singlet 2,1-Benzisoxazole

Not long ago, the occurrence of quantum mechanical tunneling (QMT) chemistry involving atoms heavier than hydrogen was considered unreasonable. Contributing to the shift of this paradigm, we present here the discovery of a new and distinct heavy-atom QMT

Pd-Catalyzed Three-Component Domino Reaction of Vinyl Benzoxazinanones for Regioselective and Stereoselective Synthesis of Allylic Sulfone-Containing Amino Acid Derivatives

A Pd-catalyzed, highly regioselective and stereoselective three-component domino allylic substitution/N-H carbene insertion reaction under mild conditions is described. This reaction demonstrates a wide substrate scope and satisfactory functional group tolerance, providing a broad range of allylic sulfone-containing amino acid derivatives. Moreover, DBU mediates highly diastereoselective cross-dehydrogenative coupling annulation of allylic sulfones without using peroxides or any metal oxidants. This developed protocol affords 7-membered ring heterocyclic compounds incorporating both sulfone-containing amino acid esters and one quaternary carbon center. Mechanistic studies indicate that an unusual umpolung of glycine occurred in this annulation.

Iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines: Synthesis of quinazolines by trapping of ammonia

A novel approach to construct 2-aryl/heteroaryl quinazolines was developed through an iron-catalyzed cascade reaction of 2-aminobenzyl alcohols with benzylamines under aerobic oxidative conditions. The reaction proceeds via the formation of N-benzylideneb