221286-31-3Relevant academic research and scientific papers
A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors
Lemaire, Wei,O'Brien, Julie A.,Burno, Maryann,Chaudhary, Ashok G.,Dean, Dennis C.,Williams, Peter D.,Freidinger, Roger M.,Pettibone, Douglas J.,Williams Jr., David L.
, p. 19 - 28 (2002)
A novel, potent nonpeptide oxytocin receptor antagonist (1-(1-(2-(2,2,2-trifluoroethoxy)-4-(1-methylsulfonyl-4-piperidinyloxy) phenylacetyl)-4-piperidinyl)-3,4-dihydro-2(1H)-quinolinone) has been identified that can be labeled to high specific activity wi
Tocolytic oxytocin receptor antagonists
-
, (2008/06/13)
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
